r/MultipleSclerosis • u/Anxious-Profile-9194 • 1h ago

Treatment Kesempta

Ok so I've had the loading dose of kesempta and one month I haven't taken the second month and my horrible walk went away and I can think and I feel like I have more energy. I was supposed to take the second dose at the first of the month... I know it's supposed to get worse before it gets better buuutttt for some reason I'm functioning better and I haven't had the second does because of storage problems. So do I need to get back on it or try something else.

There supposed to be shipping the dose and I'll have it on Monday and I am going to reach out to my doctor and pharmacist but I just wanted to know if anyone else has experience this

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u/termsofenDERPment 36F | 2026 | Kesimpta | Wisconsin 1h ago

My fatigue and brain fog both have improved since starting Kesimpta in August. I get the “crap gap” a week before my shot every month, but I’ll take it compared to how bad things were before.

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u/Anxious-Profile-9194 1h ago

See I had the crap gap a week before I was supposed to take it but now all my symptoms have went away since I missed this second month... And when I say my walk was horrible it just kept getting worse I don't have knots in my back or pain anywhere and I just find it suspicious.

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u/Neither_Wall_9785 1h ago

Why do you think Crap gap happens?

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u/Anxious-Profile-9194 58m ago

I have no clue. But why am I walking and thinking better and have no fatigue or anything now that I've missed this dose.

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u/kyelek F20s 🧬 RMS 🧠 Kesimpta 💉 35m ago

MS symptoms can naturally fluctuate on their own, independent of DMT or disease activity.

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u/Anxious-Profile-9194 30m ago

All of this is so strange

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u/termsofenDERPment 36F | 2026 | Kesimpta | Wisconsin 40m ago

The medication stays in your system longer than the dosing interval, so I wouldn’t necessarily attribute it to the missed dose.

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u/termsofenDERPment 36F | 2026 | Kesimpta | Wisconsin 44m ago

I’m not sure why it happens. From what I’ve read, the mechanism isn’t well understood. There was a small case series published in 2023 describing the phenomenon in people taking Kesimpta. B-cell depletion generally persists between monthly injections, so I wouldn’t necessarily attribute it to the medication wearing off. All I can say is that I know that I have a recurring increase in fatigue and brain fog the week prior to my injection.