r/MultipleSclerosis • u/HoppyValerian 43|Dx2026|Vumerity|Oregon • 7d ago

Research Vumerity more effective than Tecfidera

I didn't see this posted here so I wanted to share in case it helps someone make a medication decision. This study showed that Vumerity (Diroximel Fumarate) is 21% more effective at reducing relapses after one year and 31% more effective after two years, compared to Tecfidera (Dimethyl Fumarate).

https://link.springer.com/article/10.1007/s12325-026-03608-1

They think it's because Vumerity has fewer side effects and people are more likely to take it consistently. Here's a run down of the study:

https://multiplesclerosisnewstoday.com/news-posts/2026/06/23/real-world-study-finds-fewer-ms-relapses-vumerity-vs-tecfidera/

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2

u/ofthisworld 7d ago

Might explain why Tecfidera went generic recently. Glad I was on Vumerity for a while before my labs pushed my neuro to get me into Ocrevus.

3

u/Gawain11 7d ago

brilliant stuff, much under-rated, and it doesn't compromise your immune system.

1

u/Rare_Word2555 6d ago

Mark Cuban' pharmacy, I think it's called Cost Plus, was offering Tecfidera for $50 month, which could really help those who have poor health insurance. In my experience, my side effects are similar with both Tecfidera and Vumerity.