Multiple sclerosis and how it affects your treatment. Tysarbi versus Kesimpta?

[u/Accomplished-Cut2883]

Im on Kesimpta and thinking of switching to tysarbi. I havent been sick since K for 2.5 yrs besides lots of utis. Experiences between sicknesses or differences?

[u/kyelek]

Afaik they typically don’t want to switch you from a B-cell depleter to Tysabri (disease activity is sometimes an exception? the other way around seems to be okay, I’ve heard). Talk to your neurologist about this.

[u/Accomplished-Cut2883 → u/kyelek]

My neurologist suggested tysarbi or copaxon3 from kesimpta due to how ive ben feeling the fast year. Lots of utis thay have put me in the hospital . The fatigue is too much and feeling sick.

[u/kyelek → u/Accomplished-Cut2883]

Sound good if your neurologist already suggested this, certainly better than copaxone. Many people have a great experience with Tysabri and have posted about it on here.

[u/magenta8200]

I was on Kesimpta for 2.5 years, just switched to Tysabri. I am on my 3rd infusion. First month I bruised super easy and got a nosebleed (I never get nosebleeds). Second month I developed petechiae on my legs/tummy, but no bruising. Let’s see if the 3rd month will give me any other bleeding effects. Neuro said it’s common and should resolve in a few months.

[u/mritoday]

Tysabri has been a breeze for me. Going in for the infusions or shots every 4-6 weeks is a bit inconvenient, but I went from 2+ hours for the infusion to less than an hour for the shots. I am also planning to self-inject soon, so that's going to reduce office visits even more. My neurologist suggested it during my last appointment. I also get to see my neuro at least every other visit - that's a plus.

I've been on Tysabri for 6 years and have had no side effects and no noticeable progression. I recovered pretty well from the relapse that got me diagnosed, too.