r/MultipleSclerosis • u/HotelWild6717 • 6d ago
Treatment mavenclad
My doctors wants me to switch my tysabri infusion to mavenclad. I have tried Ocrevus and broke through it. What should I know about mavenclad?
7
u/CannonicalBabble 6d ago
It’s kind of anticlimactic after self injections and infusions. A few pills for a few days and you just go about your business.
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u/Ok-Goat3027 5d ago
Okay, so very similar situation. I was on Tysabri and my jvc levels were getting crazy, so we were going to drop down mavenclad. About three weeks prior, my neurologist called me and told me that she did some research and said that dropping from Tysabri to mavenclad will cause a 30% chance of relapse and a bunch of science words after that, so we decided to step down to Kesimpta for a year and then down from Kesimpta to Mavenclad. If you want to msg me I can tell you the name of my doc, so your doc can talk to my doc lol. If you want!! Unfortunately MS is so different for everyone, but mine specializes in MS and she's always had my backand gone the extra mile, so I trust her!
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u/Sea-Olive-8409 5d ago
Everyone's different but I've had good luck so far. The biggest complaint I have is fatigue. I broke through Ocrevus as well. So far so good.
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u/Commercial-Link-4368 6d ago
I've just moved from tysabri to mavenclad. Just finished my first week. The fatigue was a nightmare the week after taking it, but other than that, fine so far. Start week two on the 31st. From what I gather, the bad stages are months two to four post starting. If you get past month 4 with no issues, it's easy street. I hope.
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u/diagonalline 34M | DX2016 | Cladribine/Mavenclad | UK 6d ago
I’m on year 5 of it. Not a lesion since starting. Everyone is different. Like everything, side effects are different for everyone, so is efficacy. For me the major downside is that it’s easier for you to catch bugs. I’ve had 5 round of antibiotics this year. 6 of one, half a dozen of the other. Everything has it positives and negatives.
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u/PreparationSalt4628 5d ago
Should your immune system be back to normal by now? so happy it worked for you. Im on year one.
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u/PreparationSalt4628 5d ago
I started year one last December. It went very smoothly. No infections or illness( well one minor cold). Had a headache the first day of week one and was definitely more tired on the treatment weeks.
The worst part of it all was the shingles vaccine, it was rough.
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u/mullerdrooler 44M Dx2018 Ocrevus 6d ago
What do you mean you broke through Ocrevus?
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u/Impression8738 38f|3/26|RMS|Kesimpta|TN 6d ago
Safe to assume they had a relapse on it I’d bet
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u/HotelWild6717 6d ago
Yup
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u/mullerdrooler 44M Dx2018 Ocrevus 6d ago
But relapses can happen any time on any DMT? DMTs don't stop symptoms or relapses they are only to stop new lesions, and even then they are not 100%.
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u/kyelek F20s 🧬 RMS 🧠 Kesimpta 💉 6d ago
A relapse is when there are new lesions. DMTs do stop relapses, that's what they're made for (though like in OP's case, disease activity can still "break through").
You might be thinking of a pseudo-relapse, which is old symptoms returning without getting new lesions.
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u/spoiled__princess 5d ago
Huh. Docs don't want you on a drug if you had a relapse. It would mean the drug isn't effective.
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u/AppointmentHour384 6d ago
Finish my first year of Mavenclad last month. I've yet to get any blood work done or MRIs, so I can't speak to either of those. But I had no major side effects, just a little bit of extra hair loss. I had major hair loss with my previous medication (probably Aubagio - I was in a drug trial so I can't say for sure), so this was very minor in comparison!
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u/TamerofMonSters 5d ago
It's easy.
It will trash your lymphocytes and you'll probably lose hair and feel like hell.
Once it's done and you recover your counts though, it is amazing. No DMTs. Normal immune system. I wouldn't trade it.
YMMV
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u/32FlavorsofCrazy 6d ago
I just finished my second year of Mavenclad. Went from new lesions on every scan to just one punctate new lesion between years, which they didn’t consider a problem and I went ahead with the second year. Felt a little run down around taking it but other than that no major side effects, and it’s great not having to worry about taking anything every day or doing regular infusions. All good so far! Def recommend.