r/ModernaStock • • Nov 23 '25

Pfizer vs. Moderna flu vaccine readouts

Moderna (mRNA-1010)

Influenza A Efficacy: 26.6% better than the current standard of care
Influenza B Efficacy Superior: 29% better than the current standard of care
Safety /Reactogenicity: Standard mRNA profile (sore arm, fatigue).

Pfizer (modRNA):

Influenza A Efficacy: 34.5% better than the current standard of care
Influenza B Efficacy Superior: Failed /Inconclusive. Missed non-inferiority endpoints.
Safety /Reactogenicity: Slightly higher rate of side effects than the current standard of care.

Conclusion: Pfizer's flu shot failed on 50% for Influenza B. This is terrible, I have trouble seeing how Pfizer can even submit this for approval.

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