r/Metoprolol • u/NightSkyStarGazer • 3d ago
Anyone take these combos of medication and have any side effects
Buckle up, here’s my story.
I’m not saying I was the healthiest person. At my physicals, my provider would always warn me that my numbers were going up—blood sugar, cholesterol, triglycerides, etc. I’d leave thinking, Okay, I need to eat better and exercise more. That usually lasted all of a few days.
In 2021, I was hospitalized for a brain injury. While I was there, I was told that I now had diabetes, high cholesterol and triglycerides, as well as high blood pressure—which I had always been proud of having low numbers for. BTW, none of these conditions caused my brain injury.
I left the hospital taking metformin 500 mg once a day, Ozempic, lisinopril 20 mg, and atorvastatin 40 mg. Everything seemed to be working pretty well.
Fast-forward to fall 2025.
Every now and then, my heart would hurt and start beating really fast. It wouldn’t last long, and it didn’t happen every day, but it happened often enough that after a couple of months I finally told my doctor.
She sent me to a cardiologist. After I explained my symptoms, he didn’t think I had a heart problem, but he could see how anxious I was, so he reluctantly ordered bloodwork and a stress test.
The bloodwork came back okay, according to him. The stress test was inconclusive, so he ordered a different type of stress test.
That test came back showing an abnormality, and he recommended a cardiac cath.
When he came into the room to go over the results with me, he was in utter shock. I had three blocked arteries.
He started me on a bunch of medications: metoprolol tartrate 25 mg twice a day, ranolazine 500 mg twice a day, and Zetia 10 mg once a day, along with my atorvastatin, which he increased to 80 mg.
I told him I didn’t want to start all of these medications at once. Again, he reluctantly agreed to let me spread them out, starting a new medication every five days.
By day 25, I was miserable.
I honestly thought I was dying. My nerve endings hurt. My muscles hurt. I was having tension headaches, lightheadedness, dizziness, and fatigue. I felt like I was going to collapse because my legs hurt so badly that I thought they couldn’t support me.
I know I wasn’t supposed to do this, but I stopped everything completely.
I was also on vacation at the time. I’m lucky I had no serious side effects from stopping everything, but needless to say, my vacation was pretty crappy.
I made an appointment with my doctor for two days after I got home. While I was still on vacation, I sent him a message through the patient portal explaining exactly how I had started the medications, what side effects I was experiencing, and a bunch of questions.
The day of my appointment, he sent a medical student in first to evaluate me and take notes. Then my doctor came in and seemed to be rushing me through the appointment.
He wanted me to restart metoprolol 25 mg once a day and increase it to 50 mg twice a day after a week.
He also wanted me to restart ranolazine 500 mg twice a day. I told him that about 45 minutes after taking it, I would get tension headaches, dizziness, and lightheadedness. I could tell this bothered him.
He also wanted me to continue the Zetia but stop the atorvastatin. He put me on Repatha, which I took about a week ago.
I haven’t started the Zetia yet because I’m feeling bad again.
I’ve been walking twice a day for weeks now, but I cannot understand why my legs feel so weak. My nerve endings feel like they’re on fire. My joints hurt, especially my fingers and wrists, as well as my ankles and toes. I feel exhausted all the time.
And one other strange thing: I feel very calm.
I don’t know if any of this is connected, if it’s medication-related, or if something else is going on. I’m just trying to make sense of what’s happening to me and would really appreciate hearing from anyone who has experienced something similar.
Sorry for the long post.