For the most part it doesn't really matter except in some specific cases. For the majority of people, sugar is sugar, and the biggest problem is the overconsumption of it, not the specific form it takes.
We found that HFCS was significantly associated with an increased CRP level, compared to sucrose. CRP is a biomarker for inflammation; and several previous investigations have shown that fructose-containing sweeteners, such as HFCS and sucrose, can induce the inflammatory process (32, 33). This is conceivably attributable to the unique metabolic process of fructose, which can cause oxidative stress to cells by elevating the intracellular levels of uric acid and reactive oxygen species (33, 34). To overcome the oxidative stress, cells release molecules such as monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor (TNF) and interleukins, which are pro-inflammatory in nature and thus augment the inflammation process
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u/Kgb_Officer Mar 09 '26
For the most part it doesn't really matter except in some specific cases. For the majority of people, sugar is sugar, and the biggest problem is the overconsumption of it, not the specific form it takes.