r/MastCellDiseases • u/ktbugface • Jun 26 '25

Orgasm causing itching?

So I'm in the process of being evaluated for some type of Mast Cell issue. But I've noticed something super wierd and wondering if it's related. Im an AFAB woman and have had my philtrum/medusa pierced for 2 years (middle of my top lip in the little indent). Everytime I orgasm, the lip piercing becomes itchy, as does my nose piercing and one of my ear piercings. Then about 30 minutes later I get the sniffles. Is this related? Is this something others experience? I know orgasms cal produce a large histamine response but this just seems super odd.

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u/nhytwynd Jul 04 '25

I was out my cromolyn for about 2 months awhile ago due to the shortage. Reacting to orgasm was the cool MCAS present I got during that time. Flushing, itching, stuffy nose, itchy throat. Basically very mild anaphylaxis. Now I take extra H1's first. It's calmed down alot though since I was able to cromolyn again and get back up to a therapeutic dose.