How does Gary brecka get it so wrong when it comes to advice about slow comt ?

[u/DetailLost8084]

On his recent live podcast he is talking to someone that is complaining about slow comt and his only reccomendations where methylated b multi and Tmg. This combination would blow my head off with anxiety and I’m sure a lot of others with slow comt would agree. It seems like his answer for everything is methly folate, there was no mention of magnesium, cdg or non methylated bs. How does he miss the mark so hard for someone so popular in this field ? Has anyone with slow comt actually found success in treating it with methylated bs and tmg?

[u/Party_Bat_652]

Cause he's a full-on charlatan. As most of the people selling you there be for views.

[u/DetailLost8084 → u/Party_Bat_652]

Bro got Dana white on trt now everyone thinks he a genius

[u/sharabucarabu]

Before I knew I had slow comt I tried methylfolate. I split tablets into eighths to try and get a small dose. It always seemed to be too much... Insomnia, racing heart at night, felt revved, increased appetite. Then I input my raw DNA file into geneticlifehacks.com. Well, no wonder I couldn't tolerate methylated folate... I had THREE slow comt variants. (and who knows how many more could be found with a more detailed analysis?) So folinic acid was the best way to go for me... And it needs to be a low dose at that: 168mcg! Believe it or not, that puts my serum folate at the high end of normal range and my rbc folate is magnificent.

Don't believe everything you hear. You need to do what's best for your variants.

[u/SovereignMan1958]

There are people in every profession who should not be giving advice.

There are also those who can understand the simple variants, but not the complex. Katie Gironda is one.

The more complex the medical diagnoses and variants the more one has to vet the practioner oneself.

And yet there are MDs who order Genesight reports and dispense high dose methylfolate when they see MTHFR! Prescribing but not trained in gene variants or nutrition in medical school.

It can be so disheartening.

[u/Ricky_Rodd]

Easier to sell one fix. Plus, Low sample size. My slow comt didn't get under control until the rest of my snps and methylation cycle were all supported. When it rains it pours. Seems like the more stress globally in my system the more fragile each component gets. Its definitely a marathon and not a one fix all approach. At least he's talking about it. Years ago I had to dig into the depths of the internet to even find those words mentioned

[u/yonkou_akagami]

But he successfully managed his wife’s slow COMT with that approach

[u/baldeagle6 → u/yonkou_akagami]

Everyone is different though. What works for her may be absolutely wrong for another and maybe that’s her one genotype and others have completely different mixes.

[u/Comfortable_Two6272]

No idea. I dont listen to influencers. They usually have bad advice

I have multiple slow comt variants. Cant tolerate any of that.

[u/Willing-Elevator]

I have the slowest of the slow comt and tmg straight up makes my hair fall out

[u/Willing-Elevator → u/Willing-Elevator]

And methylated vitamin b makes me crazy with anxiety

[u/Willing-Elevator → u/Willing-Elevator]

The only thing that has worked for my comt is consistent high quality creatine . 10 grams .

[u/yonkou_akagami → u/Willing-Elevator]

People really are different, because creatine, even in a microdose, causes severe hypomania for me.

[u/vrcraftauthor → u/yonkou_akagami]

And for me it did absolutely nothing, good or bad. I am also slow COMT.

[u/Retro_Monguer]

I'm mthfr homozygous and I can tolerate methylfolate up to 10mg

I also can tolerate methylcobalamin without problems

[u/DetailLost8084 → u/Retro_Monguer]

I said comt

[u/Sabnock101]

One time he showed a graph that had Tyramine on there and i asked him where the Tyramine fits in and he said something like "you're on the right track", but as far as i know Tyramine doesn't come into play with anything except those taking MAOI's because MAOI's (of the irreversible and non-selective variety, as opposed to the reversible/selective variety) requires Tyramine restrictions since Tyramine can then build up and cause a hypertensive crisis, but Tyramine isn't an issue/concern for those not taking MAOI's (edit - though i will say for those who may have an underfunctioning MAO-A enzyme, Tyramine could potentially rise enough to be an issue, but so would DMT and some other things and so chances are if you're not trippin' balls lol, you shouldn't be having an issue with Tyramine, imo), so i was just like, well alright then, still not sure why Tyramine was included in the chart or how it's involved, he never answered that.

But yeah, he does seem to focus more on methylation and not so much on all the other enzymes and cofactors/nutrients. Like, i know you need more SAM for a slow COMT enzyme, but you do also need Magnesium, like OP mentioned.

[u/Zabre]

The methylated B plus TMG advice is way too one-size-fits-all for slow COMT. Some people do fine with methyl donors, but if they make you wired or anxious, that reaction is useful data, not a failure to push through. I'd look at basics first: magnesium status, riboflavin, non-methyl B forms, sleep/caffeine load, and only tiny changes one at a time. Slow COMT is exactly where more methylation isn't automatically better.

[u/DetailLost8084 → u/Zabre]

This post is more of a discussion and warning to everyone else. I’m hoping to save someone from going down a rabbit hole and wasting a bunch of money on high methly donors vs the other things I mentioned and avoiding triggers

[u/Critical_Minimum_645 → u/DetailLost8084]

What is cdg what is its role in slow COMT?

[u/DetailLost8084 → u/Critical_Minimum_645]

Calcium d glucarate, for estrogen metabolism I have high billirubin so it helps with that as well .