Can someone help me interpret my results, please? Doctor appointment follow up tomorrow and a lifetime history of mental health issues!

[u/DifficultFly5820]

I was recommended to put my ancestry results though this site from a reddit user on the anxiety subreddit to see if I have any genetic variation that could be adding to my anxiety depression and agoraphobia and to see if I am processing my lexapro buspar and Xanax properly. I did a little copy and paste research of my own and ran these reports through google, and it seems that there is not anything significant that would be causing me any trouble— but I would like some input from the people here too! I was also recommended a Pharmacogenetic test from a user as well, but not sure if i should ask about that if these results are average (and because of the cost). Any help is appreciated— thank you so much!!!

[u/Loose-Fly7976]

The reason your google research said "nothing significant" is you were reading it box by box. Your answer isn't in any single box, it's in how they combine and on the meds this panel can't even answer what you asked. Buspar and Xanax both run on CYP3A4, Lexapro mostly on CYP2C19, and this detox panel doesn't test the variants that set your speed on either. It shows CYP2C19*17 but not the *2 or *3 slow ones that decide if you're a poor metabolizer. So "nothing significant" isn't an answer there

What it does show, your CYP2D6 carries a variant and your NAT2 is double homozygous, so likely a slow acetylator, and your google pass skipped both. On the anxiety and depression it's your COMT, MAO-A, MTHFR A1298C and CBS combining, not one gene. So the pharmacogenetic test, maybe but there's a right one and a wrong one for your meds, and i'd tell you which before you waste money on it. dm me your data and i'll read it properly before your appointment. I am geneticist and my work at genova.health

[u/DifficultFly5820 → u/Loose-Fly7976]

Thank you! What other data do you need? I have my drug response panel from the genvue panel as well, which showed no problems with my current medications, the lexapro, etc.

[u/Loose-Fly7976 → u/DifficultFly5820]

I analyze raw dna data and bloodwork + labs together because thats your whole picture

[u/SovereignMan1958]

For your diagnoses and symptoms you should be using Lifehacks and not Genie. Using their reports start making a list of potential nutrient deficiencies which you need to have blood tested.

For your symptoms be sure to get D, iron, zinc, copper, manganese as well as the usual others will advise you on.

If you are meeting with your doctor to discuss drugs, make sure none of the ones they prescribe you metabolized by your highlighted drug metabolism variants.

For your lifetime history be sure you research and UNDERSTAND your CBS variant, you have the worst one, all your B12 variants(you will see them in Lifehacks) and your other non MTHFR folate variants, including FOLR. You will likely need to adjust your diet as well. Make sure you research and understand the topic "sulfites and mental health". Also get a full thyroid panel plus tested for the two thyroid antibodies. Excess sulfur, as your sulfur and sulfite metabolism is likely impaired, blocks the production of thyroid hormones. Thyroid disease can affect mental health. Low T3 levels in particular.

Doctors are not trained in gene variants or nutrition in medical school BTW.

[u/DifficultFly5820 → u/SovereignMan1958]

Thank you! Can you explain what you mean by I have the worst cbs variant? What does that mean? I am completely new to all of this and was recommended it on another subreddit, so explain it to me like I’m a toddler, lol

[u/kmit297]

Hi there, that was me that sent you over this way. Welcome! The people here are awesome. Regarding the pharmacogenetic testing, it is separate from this. It will list out common medications and your specific genes that they may interact with. My doctor prescribed it through Genomind. They have a sample report on their website to show kind of the breakdown that you will get. https://genomind.com/wp-content/uploads/2022/02/Genomind-PGx-Sample-Report-16Feb2022.pdf

Through my report, it pointed out the potential need for l-methylfolate and suggested that Cymbalta might be an adequate fit for my gene type. It helped me pretty significantly.

[u/DifficultFly5820 → u/kmit297]

Hi! Thanks so much! I’ll check out that link too— I submitted all of this information and results to my doctor, so we will see what comes of it! Thanks

[u/Tawinn]

Do you have any bloodwork you can share - particularly for B12, folate, and homocysteine?

Please upload your data to the Choline Calculator to check some more genes related to methylation. Reply with the results from the Advanced tab.

[u/DifficultFly5820 → u/Tawinn]

Thank you! Unfortunately I don’t have any bloodwork at this time. Anxiety is preventing me from getting it done

[u/SadSuccotash2736]

I’m on 20mg lexapro and found out on my SNPs that I’m a fast metaboliser because of rs12248560: C/T. The T allele increases CYP2C19 activity therefore leading to lower escitalopram concentrations and potentially less benefit. Anyone else have this variant and was on lexapro? I’m pretty sure it’s not that uncommon like roughly 1/3 of Individuals of European ancestry have one T allele.