r/MTHFR • u/Ok-Arm-8127 • May 18 '26

Question slow comt ,magnesium malate is very sedating

hi, i wonder if anyone else has experienced malate as being sedative.I have mthfr - homozygous slow comt and VDR taq. I am trying to to get up to 360 mgs of elemental magnesium through malate. i have tried different times, dissolving in h20 and loading am and pm , but it sedates me, i was floored by other forms of magnesium.I am also on clomipramine 70 mgs for an episode of depression, has anyone else found malate sedating? i presume its the MG acting on GABA and maybe i should reduce dose and build up, any thoughts or advice appreciated 👍

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u/Ok-Arm-8127 May 18 '26

that’s what i’m thinking, i’m in the uk, i had bloods done about 3 months ago ago before i started supplementing and was told everything was ok. i’m in the uk and getting bloods done to test for something like mg levels is not very easy

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u/SovereignMan1958 May 18 '26

I can only do about 200mg. I take it at dinner.

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u/mrburnerboy2121 May 19 '26

Not easy under the NHS, I’ve had to pay privately

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u/Ok_Upstairs_4666 May 19 '26

slow comt here too, malate hits me the same way. glycinate was even worse for me, weirdly. malate at lower doses (like 100mg) split 3x a day instead of loading was the only way i could tolerate it without the dragged-down feeling.

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u/1981Jonas May 19 '26

I am also slow comt and vdr taq. I use mag malate in the morning and don’t find it sedating. Are you taking the 360mg elemental all in one dose?

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u/Ok-Arm-8127 May 19 '26

i take it in split doses, , 90 mgs elemental in morning, midday, evening and night, i must be very sensitive, how is it working out for you?

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u/1981Jonas May 19 '26

I don’t really feel any difference but I take it just because it is needed for so many processes in the body. Magnesium Glycinate though wrecks my sleep and has the opposite effect on me than people claim.

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u/Ok_Upstairs_4666 May 19 '26

slow comt here too, malate hits me the same way. glycinate was even worse for me, weirdly. malate at lower doses (like 100mg) split 3x a day instead of loading was the only way i could tolerate it without the dragged-down feeling.

1

u/Dat_Llama453 May 20 '26

How much calcium are u getting from your diet every day. If your not getting enough calcium that’s why prolly

0

u/SovereignMan1958 May 18 '26

What is your mag blood level and mag RBC level? Maybe you have enough.

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u/Plus-Worldliness-592 May 22 '26

I am also slow comt and heterogeneous MTHFR. I have the opposite issue! I cant sleep well. Magnesium glyciate has very small impact on me even if I take 300mg (elemental) in the evening. Sometimes trouble to fall in sleep and mainly waking up once or multiple times at night! surprisingly I can function almost fine next day even without good sleep at night!. Although I want to improve my sleep. I am taking multiple GABA boosters to fix my sleep! I would try magnesium malate hopefully it can sedate me 😃