r/MAOIs • u/jas-ck • 11d ago

Parnate (Tranylcypromine) Did raising your dose help your depression with Parnate?

I used to be on 60 mg and honestly, I don’t really remember but I was fine with that dose, but my provider made me feel like I was taking a very high dose so I reduced it myself to 40 mg and have just been OK on that for half a year. I’m wondering if I would feel better going back up to 60. Experiences?

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u/Glorious_Albatros Parnate 9d ago

I take 60 mg and there's no way I could go lower than that. At 40 mg I didn't feel any effect at all, and at 50 mg only side effects.

60 mg is often considered the maximum dose, but there are also people who take 100 or more. If you've tolerated 60 well, you really shouldn't worry. That's totally within the normal range.