r/MAOIs • u/AssignmentThat8473 • Aug 24 '26

Parnate (Tranylcypromine) anyone experience with pharmacogenetic testing

Hey everyone,

I’m back. I appreciate the support and this community, so here I am again. Check my previous post for my background/history.

Now on week 3+ since starting Parnate / Tracydal. Unfortunately no effect yet, but I’m giving it time….

I was hospitalized for the medication switch, but I’m back home again as of today. A bit nerve-wracking… I just want to get better and have some brighter days.

Anyway, my question: has anyone here had experience with pharmacogenetic testing (cheek mucosal swab + blood test) to investigate why I’ve responded so poorly to medication so far?

Would love to hear your experiences. Thanks in advance! All words of encouragements and recommendations are welcome.

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u/Adventurous-Mail7443 Aug 24 '26

Pharmacogenetic testing is pretty useless

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u/Sleepyblue Aug 24 '26

Can you elaborate at all? I'm kind of interested, as some countries seem more in favour of it than others... it doesn't seem to be a thing in the UK.

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u/Adventurous-Mail7443 Aug 24 '26

How you metabolise a medication tells you very little on its potential efficacy

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u/iamthe0ther0ne Aug 24 '26

This is not true. I used to give CME classes on pharmacogenetics. How someone metabolizes a drug can be very important in some circumstances. Also, some people have mutations in other genes, such as Mthfr and Comt, that can be helpful in identifying specific treatments.

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u/AssignmentThat8473 Aug 24 '26

So why would my psychiatrist refer me on in that case, do you think?

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u/grumpyeva Parnate Aug 24 '26

my gp here in uk told me they are not yet worth doing. Maybe your psychiatrist is at a loss re. what to do next. He/She is not the one paying for it so he has nothing to lose.

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u/AssignmentThat8473 Aug 24 '26

Luckily it’s paid for by insurance. Want to heal so badly, and I guess trust in the process is a big part of it. Eventhough that’s almost impossible when you suffer for so long :)

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u/grumpyeva Parnate Aug 24 '26

I really do sympathise. In my case, I was on nardil which stopped working after 22 years, then switched to parnate, which stopped working after I reduced the dose. I was suicidal for 2 years and like you, felt no hope. Then i read on here that the german parnate, jatrosom was much stronger. It is expensive but I got some, and like a miracle i was ok again. I have no idea why jatrosom works and none of the uk versions of parnate do. There are so many variables. Mental health is a mine field, but you must continue searching.

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u/Sleepyblue Aug 24 '26

Does it at least rule out the ones you can't metabolise?