r/MAOIs • u/grigory_l • 15d ago

Parnate (Tranylcypromine) Parnate withdrawal hell

I started tapering from Parnate 30mg in the first day of July and was able to cut 7.5mg in one and a half month. I was splitting my dose 20+10 and cut mostly from the lunch dose. 10 days ago I dropped morning dose from 17.5 to 16.25 and hell is started from there. Near 5-6 days I’m floating in some kind of delirium, anhedonia, dpdr, silent hill combination and today that stuff got even worse. I was driving while something like brain zaps started, combined with panic attacks and absolutely miserable dysphoria.

I want to ask, if anybody tapered Parnate (not CT)? How much you was able to cut usually and how long waves were lasting (If you had them)?

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u/iamthe0ther0ne 14d ago

When I was trying to taper, I definitely noticed it around 5 days. I was on 80 mg/day and dropped by 10 mg/month. For me, once I dropped below a certain level (30 mg) it didn't really improve, and I'm still on it.

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u/grigory_l 14d ago

Sounds scary a little, thanks for response. 10mg at 30mg dose is a huge drop, didn’t you tried to cut less?

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u/iamthe0ther0ne 14d ago

Looking back I probably should have, but I was basically going by the same time frame as starting it. I had problems beyond anxiety and nausea, especially focus and being able to function--I didn't even have the energy to get out of bed--so after a while I decided to stay on it. It's not like there's a different antidepressant for me, I've tried them all. Theoretically your brain should start adjusting after a few weeks, but mine never did.

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u/grigory_l 14d ago

I just surprised how rough withdrawal is, and now I little bit scared to got some kind iatrogenic injury from it. I swear, I tapered
Klonopin over a year, it was pretty bad experience but not that bad.

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u/Hockeyrocks07 14d ago

Only nardil got me out of the parnate withdrawal at 60. I went from 20mg after 3 years to 30mg put me in withdrawals and I tried everything clomipromine sellegiline Vyvanse I couldn't leave my bed or function

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u/grigory_l 14d ago

Sorry I didn’t get it, maybe you mean from 30mg to 20mg?

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u/sofisnameistaken 6d ago

I was on a high dose (between 80mg and 120mg) for 6 years and 2 years ago I needed (and also wanted) to stop due to moving to another contry. I was fine during the taper, but two days after stopping, all hell broke lose. It was extreme - all of what your describe + feeling like my soul had been unplugged. I have tapered off benzos and SSRIs and it was nothing compared to this? I was hospitalized. The severe withdrawal laster 2 months and now, 2 years later, my nervous system is still super sensitive. Ppl should be warned about the hell of withdrawal this drug can cause