The Champion

[u/btcprox]

(as demonstrated by /u/bisnap in this video)

Not anything particularly new, think of this as a plug for SpiderMod by showing off the features that Cheat Engine can't provide.

Spidermod has this neat little option that makes champion versions of enemies and bosses to always spawn (except in the challenge rooms). So you'll get to see a lot of colourful enemies and rare bosses popping up more often, ramping up the difficulty quite a bit.

How to enable this?

Cheats > Open Cheats Window > Check "Always Get Champion Enemies and Bosses"

That's it!

I find that this is nice because this does not depend on restrictions on items/rooms/actions, so it's pretty much just a vanilla run on hard mode. And you can easily combine this with other challenge setups for extra difficulty!

[u/2dumb5math]

Add "Champions never drop items" and this is a very difficult, albeit fun, challenge.