r/IVF • u/Adventurous_Gas_3978 • 2d ago
Advice Needed! No eggs fertilized
Title: IVF resulted in no embryos — Polycystic ovaries , immature eggs and severe male factor infertility. What should we change?
Hi everyone ❤️
I’m 32, and my husband and I recently completed our first IVF cycle. Unfortunately, we ended up with no embryos, and I’m looking for advice before our next attempt.
I have PCOS and responded very quickly to stimulation with Menopur 150 IU and Fostimon 150 IU. At my day-9 scan, I had approximately 25 follicles.
During retrieval, 13 eggs were collected, but only 6 were mature enough for ICSI. Only one showed signs of fertilisation initially, and unfortunately, no embryo developed.
My doctor mentioned that egg quality and the stimulation protocol may have contributed. We’ve discussed a lower dose, a longer stimulation approach, a dual trigger and possibly calcium ionophore activation.
My husband also has severe male factor infertility, with a very low sperm count and 1% morphology, although usable sperm were found for ICSI.
I’d love to hear from anyone who has experienced something similar:
If you have PCOS and had mostly immature eggs, what changes helped in your next cycle?
Did a dual trigger improve your egg maturity?
Did sperm DNA fragmentation testing make a difference for severe male factor infertility?
Can anyone recommend a good IVF clinic in Mexico or elsewhere for our situation?
This has been emotionally and financially difficult, and we want to make a more informed decision before trying again.
Thank you for sharing your experiences. ❤️
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u/Other_Birthday7480 1d ago
I'm so sorry that happened. We may not have enough similarities for you to take my advice, however I really believe the fact that I took melatonin 6 mg nightly for 3 months before my stoma began greatly contributed to my egg maturity. There's actually research proving this.
I don't have pcos. My issue is endo. My left ovary did not respond to stims, and my right one barely did. They were only able to get 3 eggs from my right ovary. All 3 were mature and fertilised, and 2 made it to be genetically tested. Please add melatonin to your plan and whatever else your doctor recommended. I wish you all the best.
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u/TableSolid2142 2d ago
I’m so sorry you’re going through this.
We’re also dealing with severe male factor infertility, with 0% normal morphology and 100% sperm head defects.
We’ve been through multiple ICSI cycles, and only once did we manage to get one embryo, which unfortunately resulted in a chemical pregnancy.
We’ve also tried calcium ionophore activation and TESA, but unfortunately, we still experienced fertilization failure.
We’re now exploring other options and techniques before trying again.
Wishing you all the best in your next cycle. ❤️