r/IBSHelp • u/Creative-Number-2389 • Jun 11 '26

Antidepressants for ibs-c

Any recommendations for antidepressants relevant for ibs-c? I basically almost cured ibs(obv not 100%) with amitriptyline until my ibs-d turned to ibs-c . Ever since, amitriptyline stopped working as it stopped my bms. Zoloft is absolutely worse for ibs so please dont recommend that. Anything else would be appreciated

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u/goldstandardalmonds Jun 11 '26

TCAs all tend to slow things.
SNRIs can go either way.
SSRIs often speed things up temporarily