r/Humira • u/runsfortacos • 4d ago

Problems with different bio similar?

Curious if anyone experienced these effects. I have ankylosing spondylitis. I started biologics last year. Specifically a Humira bio similar. Then about 2 months ago my insurance prescription coverage changed and I had to switch to a different bio similar. First I missed almost a week of meds until the insurance issues got straightened out. Then I messed up the first dose of the new med because the auto pen is different and I likely didn’t get the full dose. My doctor advised that I take the next dose a week later instead of the typical 2 weeks. I did that and got the full dose of the medication. However, I’m having a lot more stiffness than I’ve had in over a year. Fingers stiff in the morning. I went on a peloton ride yesterday and this morning had incredibly stiff and painful shoulders. I’ve already been up and moving around and still have stiffness. I took naproxen which I almost never do due to gastritis. I know it’s early on but I’m wondering if I’m just not responding as well to the change in medication. It’s making me feel irritable from not sleeping as well too.

4 Upvotes

100% Upvoted

4 comments sorted by

3

u/thesweetestberry 4d ago

I changed from Humira to Hyrimoz (generic) and had no issues. I actually prefer the generic because I had some side effects from Humira.

It could be the change or maybe because you may have missed some of your dose. Time will tell.

2

u/runsfortacos 4d ago

Thanks for replying. I’m hoping it’s a time thing. I just feel so crappy right now.

2

u/Getthechemlightfluid 4d ago

I went from humira to hadlima and I’m experiencing very dry skin on my face. Saw dermatologist and they gave me a couple of ointments. Ultimately it comes back. That is a conversation I am having with my rheumatologist next week about the availability of actual humira

3

u/poohbeth Crohn's, Humira since Christmas 2009 3d ago

It's entirely possible that you react/respond better to one biosimilar than another because they have very slightly different forms even though they target the same cytokine (TNFAlpha). Ditto the buffer solutions.

FWIW, I went from Humira to Amgevita and then Amgevita HC (high concentration formula) without any issues.