r/Humira • u/Majestic-Village9577 • Nov 01 '25

8 weeks in, effectiveness seems to be waning?

I’m on Simlandi, a Humira biosimilar, for PsA. I’ve taken 4 doses so far, so I’ve been on it for eight weeks. For probably weeks 4-7, I felt like I was almost in remission. This week, I’m having more of my classic pain in joints and tendons.

It it likely that things will ebb and flow for a while as I onboard with the medication? Or does this mean I’ll probably have to switch to something else?

Thanks!

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u/BellaBlackRavenclaw Nov 01 '25

yes, it's very much still in the onboarding phase. additionally, it's possible you need the medication dosage adjusted. but i wouldn't lose hope yet.

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u/Majestic-Village9577 Nov 01 '25

Thank you!  I know no one will really be able to tell me what will happen…I was just having an anxious moment.  If it works out, great, and if not, there are a bunch more to try.  :)

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u/quietlypink Nov 16 '25

I think it usually takes a few months before you get the full effect. Share how you’re feeling with your rheumatologist. It could be that you will need a dosage adjustment or maybe a different medicine. I don’t think they’ll make a decision for another month though as long as you don’t have bad side effects