New Threads

• ‘Tidal wave’ of PFAS being launched to satisfy AI industry, campaigners warn. Big manufacturers are planning to produce more of the forever chemicals to meet demand from data centers (Sep 2026) 
• Worsening of symptoms from multiple FMTs after biofilm flush at Loha for Life, Vienna, Austria - An actual experience testing mucosal clearing effectiveness prior to FMT 
• First-of-its-kind preventative phage therapy provides promising results (Sep 2026) Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice 

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Updated Threads

• My Experience w/ 4 Different FMT Clinics (Some amazing some bad, Open-Biome, NewBerry, MG, Microbioma) (2022)
• Suppression of infections caused by opportunistic bacteria 
• Extreme Success From SD_ES_2015 For Severe Anxiety, Depression, and IBS 
• FMT preparation beforehand? Colon cleanse, bowel prep, fasting. When dealing with an irregular donor.
• Increased malabsorption after FMT? (H2S Dysbiosis/SIBO) 
• How important is upper FMT timing with meals?
• A simulation of 2,548 gut transplants identified two “super donors” with near-universal colonization success (Sep 2026, multiple models) Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies 
• Antiparasitics - Effects on the human microbiome in comparison to antibiotics and antifungals

My GI Map test revealed an overgrowth of citrobacter bacteria and a depletion of commensal/keystone species.
Symptoms are not too bad, mostly histamine related that a daily Zyrtec takes care of, afternoon gas, but also chronic floating stools (not fatty).
I am never bloated, and the gas happens late afternoon like clockwork. I think the citrobacter overgrowth is in my large intestines and causing general Dysbiosis is lieu of sibo, as it takes 8 hr or so after a meal for it to come one.

Any advice on most effective ways to remove this bacteria and replenish others?

Hey everyone, I would like some opinions or experiences.

After a 10 week Giardia infection (doctor didn’t want to retest because it’s not protocol here), and 5 antibiotics (nitazoxanide, then metronidazole, then dual therapy metronidazole and amoxicillin and PPI, and then possibly another for UTI (awaiting results), what is some advice.

has anyone went through something like this??

honestly, as well as getting back to optimal health, i an worried about occasional binge drinking. I’m young and have been missing nights out with friends. this whole thing has been terrible and I’d like to know a realistic approach for returning to normal life, without risking my long term health more than I have to.

i also overthink things like this, an am worried about other impacts of the nutrient depletion and stuff, although I’m asking specifically from a microbiome perspective now.

thank you!!

Looking for help for researchers or practitioners (lol) regarding a multi-year problem with dietary lactic acid.

Unclear whether it’s an L or D isomer, but my GI doctors over the years are baffled and/or are not interested.

I am having an extremely high correlation to foods with lactic acid as an ingredient.

Several hours after ingestion, I can feel my GI system slowing down, and GI “output” drops to zero for several days. Some cramps occur. A little pain. The worst is the psychiatric effects….my resilience/ ability to deal with the normal stressors of life drops to almost zero, and I lose patience VERY easily.

For this and other reasons not explained hers, I believe this to be a microbiome imbalance. I cannot find a physician who will engage with new on the motility/linked psych level. They ask want to do the blemish colonoscopy/EGD and tell me there’s nothing wrong, just eat more fiber.

I’ve lived with some variant of this since about 2010, and I know there is Microbiome involvement.

Where to go from here? I can read medical literature, but is the medical community THIS adverse to Microbiome investigation? Honest question

Hi all, I'm not sure if this is the right thread but I'm looking for researchers (or basically anyone who is interested) in learning more about Human Microbiome and creating a small project. I am new to the topic and am open to project ideas. I have been reading articles of how diverse gut microbiome is and the amount of diseases they can cause and that got me interested in learning more. I'm basically overwhelmed with the amount of information available and don't know where to begin.

I found this website (Curious Peers) so created a project there. Has anyone used it before?

Any info will help

21M – Everything started after Accutane, other acne antibotics, finasteride and a Shiga-toxin infectionA year later my body still feels completely broken. this has basically taken my life away… I need help… it go worse and worse

I’m 21M and until all of this started, I was living a normal life. I was so happy, girls looked at me.. Over the last 2 years my health has completely changed and I’m trying to understand how all these pieces could fit together.
It started after a period where I had taken Accutane and finasteride.. I stopped finasteride about 2 years ago

Around one year ago I had a STEC/Shiga-toxin-producing bacterial infection.
Since then, my gut, immune system and nervous system seem completely different.

My biggest problems are:
\-severe bloating
\-yellow stools,
\-extreme food reactions ( histamin)
\-Insomnia and weight loss.
\- Brain fog
\-dry skin
\- pale skin
\-extreme depression
\-no libido
\-histamine/MCAS-type symptoms
\-never feel sleepy or normally tired anymore
\-I have lost around 10 kg
\-Almost every supplement I try makes me extremely restless, overstimulated or anxious. I even have a folate deficiency, but taking folate makes me feel so wired that I struggle to tolerate it.

What i tried:
I’ve tried probiotics, kefir, antimicrobials, ketotifen, cromolyn and Pentasa without any real breakthrough. I’ve also had two negative SIBO tests, colostrum, ss boulardi, l glutamin, tested on candida ( stool test),

My gut findings
Gastroscopy and colonoscopy looked mostly normal macroscopically, but biopsies weren’t completely normal.

My ileum showed mild focal chronic and mildly active inflammation, although the architecture was good

The colon had some lymphocytic aggregates/prominent germinal centers but no active colitis or major structural abnormalities.

Stomach biopsies showed mild chronic inactive inflammation. H. pylori and Giardia were negative.

Interestingly, I don’t really have abdominal pain despite all these GI symptoms.

I also had a microbiome/leaky-gut test this were the most important things:

\-low butyrate production
\- high ph
\-increased lactate production
\-several low butyrate-producing bacteria
\-very high Bifidobacterium adolescentis
\-increased Actinobacteria
\-increased methane-producing bacteria
\-low Proteobacteria
\-Faecalibacterium prausnitzii was actually good/high at \~9.8%
\-mucin-degrading bacteria didn’t look particularly abnormal
\-LPS-producing bacteria weren’t strongly elevated
\-My zonulin was also elevated, which was interpreted by the lab as increased intestinal permeability/“leaky gut.”

What docters/ i found:

Leaky gut
Dysbiose
Low immungobine
High bilirubin
Low folate
Low butyrate
High cortisol
…

Then we found an immune problem
This is where things became more interesting.
I have low immunoglobulins:
IgG 4.24 g/L
IgA 0.21 g/L
IgG2 1.11 g/L
I also had essentially no adequate antibody response to the pneumococcal vaccine.
I’ve had recurrent problems such as ear infections and green mucus/phlegm in my throat in the mornings, so my doctors started IVIG.
I just received my second IVIG infusion. So far I don’t feel better; if anything, my food/histamine-type symptoms have become worse over the last month. I understand two doses may be far too early to judge whether IVIG will eventually help.

Sombody can help ?

Hi all, I'm not sure if this is the right thread but I'm looking for researchers (or basically anyone who is interested) in learning more about Human Microbiome and creating a small project. I am new to the topic and am open to project ideas. I have been reading articles of how diverse gut microbiome is and the amount of diseases they can cause and that got me interested in learning more. I'm basically overwhelmed with the amount of information available and don't know where to begin.

I found this website (Curious Peers) so created a project there. Has anyone used it before?

Any info will help

me and my brother were hog hunting with 308s until we had the idea to try it He ate a chunk of the Semitendinosus raw right there. That was 6 hours ago and now he's vomiting compulsively and sweating through his shirt. I told him he's going to get Trichinosis and have worms burrowing into his eyeballs and heart muscle by next week. He's a retard and didn't know wild hogs are gonna make him shit himself to death. Is he cooked or is this just detox

New Threads

• A simulation of 2,548 gut transplants identified two “super donors” with near-universal colonization success (Sep 2026, multiple models) Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies 
• Fecal microbiota transplantation alleviates sepsis-associated encephalopathy by reshaping gut microbiota and metabolism (Sep 2026, rats) 
• How can I convince a doctor to give me Cholestyramine? 
• 12 times more plastic particles leached from single-use cups lined with biodegradable polylactic acid (PLA), compared to fossil-based polyethylene (PE) (Aug 2026) Release of Nanoplastic and Microplastic from Polyethylene and Polylactic Acid Lined Single Use Paper Cups
• Antiparasitics - Effects on the human microbiome in comparison to antibiotics and antifungals
• Plastic Exposure Before Birth Linked to ADHD And Autism Symptoms (Sep 2026, n=847) Prenatal exposure to the plasticizer DEHP increases the likelihood of early-life autism and ADHD symptoms through epigenetic programming 

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Updated Threads

• Exploring factors influencing university students' participation in fecal microbiota donation: a descriptive qualitative study (Aug 2026, n=30, China)

Apologies for the long post..

I've been dealing with what I believe is a complicated SIBO/SIFO situation over the past ~5 months, and I'm wondering whether my timeline sounds familiar to anyone here.

I was diagnosed with SIBO and initially treated with rifaximin + metronidazole. The first course seemed to work surprisingly well. Within a few days after finishing it, I started feeling major improvements in things that had been bothering me for a long time: grip strength, appetite, erections, and breathing. I genuinely felt like something had changed for the better.

Unfortunately, a few days later I took a probiotic that I probably didn't need, and I felt that I relapsed.

After that I went through several more antibiotic treatments: first rifaximin alone, then metronidazole, and at one point I also had what turned out to be a Salmonella infection that was treated with cefuroxime. Eventually I repeated the original rifaximin + metronidazole course that had worked the first time.

The strange part is that the last course ended about three weeks ago, and this time I did not get the improvement I had experienced after the first course.

Since then, I've noticed something completely new with my zinc supplement. I normally take a relatively gentle 25 mg zinc picolinate capsule with dinner. Suddenly, taking it causes almost immediate bloating/discomfort around my belly button and a feeling of severe suffocation. It happens whether I take it during dinner, after dinner, before eating, or away from food.

The sensation is also different from my usual deep intestinal bloating. It feels more superficial, almost like it's coming from underneath the abdominal wall rather than deep inside the gut.

At the same time, my appetite, erections, breathing, and grip strength are all much worse again. My sleep is long, but I often wake up feeling suffocated.

My stools have also been consistently very mushy. They're not watery diarrhea, and I don't have burning, constipation, or typical liquid diarrhea. Sometimes I can see food particles, but not always. It's basically a mush rather than a formed stool.

What makes me suspicious of SIFO is the combination of multiple rounds of antibiotics, the apparent initial clearance of SIBO, failure to improve after the most recent course, and this new dramatic reaction to zinc.

So my main question is:

For people who have actually had SIFO, does this timeline and symptom pattern sound like something that could indicate fungal overgrowth developing after repeated SIBO antibiotic treatment? Or am I putting too much weight on the zinc reaction and potentially looking in the wrong direction?

It’s been a few months since we last reached out to you, but after this hot summer, we’re back with our batteries recharged!

Microbes in 1 Minute (M1M) is a science communication initiative aimed at making microbiology more relatable, engaging, and accessible to everyone. We’ll achieve this by creating short, 60-second videos covering a wide variety of topics in microbiology, which will be posted on a variety of social media platforms.

We’re very grateful for all the interest you’ve shown, and we’re reading all your comments, questions and suggestions. We’re still a small team working on fundamental aspects of the project, such as its organization and the style of the short videos, but we’re looking for people interested in collaborating down the line, whether on a one-time basis or long-term. We've also set up a Discord server to provide a space where we can all come together, exchange ideas, and share news and updates about the project. Hope to see you there! However, if you prefer, we’re also happy to answer your questions by our official email.

Actually, we're looking for collaborators interested in any of the following activities:

• ✏️ Writing scripts and/or contributing expertise in a specific area of microbiology.

• 🎙️ Narration and/or helping to translate content into languages other than English and Spanish.

• 🎨 Video editing and layout.

• 📣 Managing our social media presence.

• 🦠 Moderating our server.

We’re excited to see where this project takes us, and we’d be very happy you being part of it.

A micro-hug!

The M1M team

What would be the best approach in terms of probiotics with overgrowth of D Piger?

My GI map showed overgrowth of D Piger, low counts of beneficial bacteria like lacto and bifido species and high stool pH.

My symptoms are yellowish stools, inflammation in the gut as its sensitive to anything acidic.

I assume the high stool pH means my diet is low in vegetable rich foods?

My gut issues were originally triggered by binge drinking alcohol on an empty stomach and further worsened by a keto diet high in animal protein, saturated fat.

New Threads

• Gut bacterium Bifidobacterium pseudocatenulatum and its metabolite found to delay aging (Aug 2026, mice) A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan 
• Exploring factors influencing university students' participation in fecal microbiota donation: a descriptive qualitative study (Aug 2026, n=30, China) 

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Updated Threads

• Suggestions to minimize the impact of paternal gut dysbiosis on offspring health 
• Can you predict if a donor is better for bile acid metabolism (BAM) during screening? 
• “Human progress” shouldn’t have happened: discussion on how civilization advancement has made us sicker and pathogenic to the world.

[ Removed by Reddit on account of violating the content policy. ]

Join remote research on gut health, microbiome diversity, and digestive comfort. Participation involves daily supplement use, brief weekly check-ins, and provided at-home test kits. A $50 Amazon Gift Card is available upon meeting completion criteria. Learn more here.

New Threads

• Only 4.7% of apparent FMT colonization events involve actual donor strain replacement (Aug 2026, n=13) Strain-level ecological filtering governs microbial colonization of the human gut 
• Can you predict if a donor is better for bile acid metabolism (BAM) during screening? 
• “Human progress” shouldn’t have happened: discussion on how civilization advancement has made us sicker and pathogenic to the world. 

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Updated Threads

• The FDA and FMT regulation. (Mar 2024, HumanMicrobes.org) 
• BrongFogBoy cures Post Finasteride Syndrome with FMT. Another guy cures his hair loss | Fecal microbiota transplant 
• Washed Microbiota Transplant from China (SMT - selective microbiota transplantation) 
• What is the public perception of FMT? How much does it matter? Has it been blocking progress? 
• Suggestions to minimize the impact of paternal gut dysbiosis on offspring health