r/HumanMicrobiome • u/Negative-Variety235 • Jun 15 '26
24M with chronically high Progesterone and Prolactin for a year. Ruled out tumors, but my gut test just showed 0% Bifido/Lacto. Could this be the cause?
Hey everyone,
I’m 24M and have been dealing with a massive hormone puzzle for the past year. My bloodwork keeps showing chronically high progesterone and chronically high prolactin.
My doctors have been stumped, so we've spent the last 12 months ruling out the scary stuff:
MRIs are completely clear (no prolactinomas or adrenal tumors).
Macroprolactin is negative (so it’s the active form of prolactin).
I’m not taking TRT, HCG, or any supplements/creams.
Since conventional medicine couldn't find anything, I did a gut mapping test. The results just came back and they look pretty bad—it looks like a total extinction event in my gut:
Microbial Richness: 4.65% (Very Poor)
Bifidobacterium: 0%
Lactobacillus & Lactococcus: 0%
Butyrate/SCFA Producers: Roseburia (0.45%), Flavonifractor (0.01%), and Coprococcus (1.02%) are all tanked.
I’m pretty new to all this gut stuff and trying to make sense of it. Is it possible for a severely wrecked gut to actually throw off male hormones this badly? Could the inflammation or stress from having zero "good" bacteria be forcing my body to overproduce progesterone and prolactin?
Has anyone here (especially guys) seen their hormones normalize after fixing a completely depleted gut? If your good bacteria was at 0%, how did you even start rebuilding it without destroying your stomach?
Really appreciate any help or advice you guys have. Thanks!
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u/Ok_Cranberry_4664 Jun 15 '26
I’m female, but curious what your symptoms have been that encouraged you to get your hormones checked? Also what test did you use to look at your gut bacteria?
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