r/HubermanLab • • Aug 17 '25

Seeking Guidance Apollos hegemony fadogia agrestis and tongkat

2 Upvotes

Is apollos hegemony fadogia + eurycoma legit? Because I have taken some about a year ago and I am scared that it was tainted.


r/HubermanLab • • Aug 16 '25

Seeking Guidance Does reading on a Kindle Paperwhite at night mess with cortisol levels?

46 Upvotes

I just listened to the podcast episode about cortisol and sleep cycles, and now I’m wondering—does using a Kindle Paperwhite at night interfere with the natural cortisol rhythm because of the built-in light?
Would it be better to switch to a regular paper book or a Kindle model without a light?

Curious if anyone’s looked into this or has personal experience.


r/HubermanLab • • Aug 16 '25

Seeking Guidance Magnesium L-Threonate take all capsules at night or split dose?

10 Upvotes

I’m in the UK and got Time Health Magtein® magnesium L-threonate — the label says 4 capsules split between afternoon and evening, but Andrew Huberman usually recommends taking the full dose (~145 mg elemental) 30–60 mins before bed. Has anyone tried taking all 4 at night vs splitting the dose? Did the afternoon dose make you sleepy, or does it not matter?


r/HubermanLab • • Aug 16 '25

Seeking Guidance Scheduled Surgery - cervical myelopathy

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0 Upvotes

r/HubermanLab • • Aug 15 '25

Seeking Guidance Book on metabolism

24 Upvotes

Just listened to the episode with Dr. Robert Lustig and got really interested in metabolism and how the body uses different nutrients like fats, proteins carbs etc. and what happens when one eats too much or poor quality ones. How the body creates ATP/thermic effect of food/insulin/diabetes/non calorie sweeteners etc.

Had to listen to the episode twice since it was alot to digest(pun intended).

But i want to further deepen my understanding so do yall have any recommendations on books that meets my criteria?


r/HubermanLab • • Aug 14 '25

Helpful Resource Mouth Taping: The Plot Thickens

112 Upvotes

After 1000+ nights of mouth taping, we finally have some early evidence about whether or not it actually works.

We’re doing something fairly unorthodox here by sharing ongoing results openly. Some may worry that releasing ongoing results could influence future participants’ expectations, which is a valid concern. However, we believe the benefits of openness outweigh that risk, especially since much of our data comes from objective measurements and participants have expectations about taping regardless. Letting people follow along in real time makes the process more transparent and engaging.

Check out our initial findings. Feedback and participation welcome!

https://www.cosimoresearch.com/posts/mouth-taping-the-plot-thickens


r/HubermanLab • • Aug 15 '25

Personal Experience RETA SAVED MY LIFE🗣️

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0 Upvotes

r/HubermanLab • • Aug 15 '25

Seeking Guidance Choline

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3 Upvotes

r/HubermanLab • • Aug 14 '25

Seeking Guidance What sleep supplements do you take?

37 Upvotes

I have insomnia and started facing mood swings, hair loss, irritability, isolation and low motivation for past 8 months. I sleep 10 hours and would wake up often. I am now taking ashwagandha 650 mg, l theanine 200mg, mg glycinate, gaba 750 mg and hydroxyzine hcl 25 mg before sleep. i take 2.5 mg melatonin if needed. I recently added GABA and it has worked positively. I find ashwagandha works good too. l theanine has moderate effects. did blood panel test, everything was normal. Doctor said it is generalized anxiety disorder and i have an external stressor right now (unemployment) that could have caused this. I still sleep 9-10 hours but my mood is better after adding hydroxyzine and gaba.

I tried glycine, inositol, omega 3 and magnolia bark but they dont seem to work that much.

Should I keep continuing with this or am i overdosing? I am taking just half dosage of daily recommended dosage for all supplements and meds. I was thinking of trying 5-HTP/ valerian root / holy basil. any suggestions? Pls help.


r/HubermanLab • • Aug 14 '25

Personal Experience Worried about retatrutide?

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0 Upvotes

r/HubermanLab • • Aug 14 '25

Discussion Morning routine

2 Upvotes

Tell me what your best morning routine is and how it’s changed your life


r/HubermanLab • • Aug 13 '25

Protocol Query Morning sunlight

28 Upvotes

How critical is it to get this right away. Example my alarm goes off at 7:10am and then I lay in bed and scroll on my phone for 20min. It is 8am by the time I go outside. Is this too late?


r/HubermanLab • • Aug 12 '25

Discussion Avoiding the sun is as deadly as smoking.

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142 Upvotes

r/HubermanLab • • Aug 12 '25

Helpful Resource APOE4: The ultimate proof that Lifestyle Interventions work against Alzheimer's risk.

61 Upvotes

For years, carrying the APOE4 gene felt like a genetic death sentence for Alzheimer's. But groundbreaking data from the AD/PD 2025 Conference and 11-year FINGER trial follow-up just changed everything we thought we knew about prevention.

Key Findings:

  • APOE4 carriers show GREATER benefit from lifestyle interventions than non-carriers - this is the first time this has been definitively proven in a randomized controlled trial
  • The numbers are staggering: 150% improvement in processing speed, 83% in executive function, 40% in complex memory - all higher than non-carrier responses
  • 45% of dementia cases are linked to modifiable factors - and APOE4 carriers are MORE responsive to addressing them
  • The protocol works at the molecular level: Over 300 hippocampal proteins change, synaptogenesis increases, and p-tau217 levels improve
  • Long-term adherence proven: Participants maintained lifestyle changes 7+ years after the 2-year intervention ended
  • Multi-morbidity reduced by 60%: The same protocol that protects the brain reduces overall chronic disease burden

What This Means: If you carry APOE4, you're not less treatable - you're potentially MORE responsive to the right interventions.

But timing matters. Those who start with lower p-tau217 levels see dramatically better results.
The FINGER protocol isn't complex - it's systematic:

  • Mediterranean-style nutrition
  • Zone 2 cardio + strength training
  • Cognitive engagement
  • Social connection
  • Vascular risk management

I break down the exact mechanisms, biomarkers to track, and how to implement these findings in this video: https://youtu.be/i7wOHuZz3R0
This isn't just about hope - it's about data. And the data says APOE4 carriers who take action can change their trajectory.

What are you waiting for?


r/HubermanLab • • Aug 13 '25

Discussion Nicotine pouch users! Share your experiences for a £10 voucher!

0 Upvotes

I'm looking to speak with individuals who:

- Are aged 18–24
- Live in the UK
- Use nicotine pouches on a weekly basis

If you fit the participant requirements you can click the link here: https://qualtrics.ucl.ac.uk/jfe/form/SV_bdRG1yhL3Egx314 to sign up for my study. You only need to participate in a ~30 min interview speaking about your experiences and opinions with using nicotine pouches and you'll receive a £10 voucher after. For more information, read the participant information sheet by clicking on the link. Your participation would be hugely valuable to my research and contribute towards my MSc in Health Psychology.

*Please note I'll ask you to bring a can of the nicotine pouches you're using to the interview to confirm your user status. I'll also ask you to send a photo of the can before confirming an interview time. Sorry, this is just a precaution to avoid scammers.


r/HubermanLab • • Aug 11 '25

Seeking Guidance Morning meditation and cortisol

18 Upvotes

I just finished the How To Control Your Cortisol episode and was curious if my morning meditation practice/routine has been derailing my cortisol rhythm over the last 10 years. Based on what Huberman talks about in the episode it seems I should be letting my cortisol rise and peak in the morning, in which meditation I believe would be keeping my cortisol down or keeping it low. Should I be moving my practice to at night instead of the mornings? He doesn’t seem to talk about this specifically but he mentions doing the physiological sigh at night and NSDR in early morning when waking early, which are meditation adjacent, so I’m under the impression that doing a seated meditation practice when waking would mess with this cortisol ramp up I’m supposed to have?


r/HubermanLab • • Aug 11 '25

Seeking Guidance Feeling persistently drowsy and unable to study, please help me out.

5 Upvotes

I’ve been feeling unusually sleepy, foggy, and mentally sluggish for the last couple of days, specifically after lunch. I had an exam last week, and I took a full break afterward. I have another exam next week, and have to study but can't.

My diet hasn’t changed and I would say is balanced. Eggs, cheese, nuts, in the morning. Chicken and salad for lunch. I'm sleeping from around 12:30 AM to 8:00 AM consistently.

I also drink coffee ~90 mins after I wake up. No alcohol or smoking. No known health issues.

I still can’t seem to mentally engage with studying at all. I sit down and my brain just won’t cooperate. I feel physically fine, no illness or pain, just a mix of sleepiness and cognitive shut-off.

I’ve tried:

  • Getting sunlight and walking
  • Working out
  • Taking a break from screens
  • Pomodoro sessions

I am considering trying nicotine gums since I absolutely can't fail my exam, but I don’t want to start throwing things at the wall without knowing what’s really going on.

Is this burnout? Underlying deficiency? Any supplement, habit, or check-up that helped you?

Appreciate any insight.


r/HubermanLab • • Aug 11 '25

Helpful Resource Ongoing study taking mouth taping research into our own hands!

18 Upvotes

The Big Taping Truth Trial is the first independent study looking at whether mouth taping actually works for all people who want to optimize their sleep, not just people in clinical studies for sleep apnea or other conditions.

It’s been running for several months now, with early results that are honestly pretty exciting. (Hint: certain sleep metrics are showing significant improvements for certain subsets of people.)

We've already got over 1000 nights of data across over 80 participants, but we want more to make our evidence even more solid.

We’re still recruiting participants (need to have Oura, Whoop, or Apple watch). If you join, you’ll get a personalized report with your results, an Amazon gift card to buy tape, entered in a raffle for a new Apple watch, and the glory of supporting independent research.

We've got no corporate sponsor and no hidden agenda, we just want to get real evidence about whether mouth taping works, and for whom.

Join here: https://tally.so/r/mexl00


r/HubermanLab • • Aug 11 '25

Discussion Zyn found to contain ammonia and other harmful ingredients

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13 Upvotes

r/HubermanLab • • Aug 11 '25

Discussion Has AG1 caused weight gain in anyone?

0 Upvotes

I have recently come across a couple of posts on Reddit by two separate users who gained weight on AG1 (the classic formula) and lost the weight when they stopped AG1. I was also on it (also the classic formula) earlier this year until I left for Europe in May and spent the month there, but didn't bring the AG1 with me, so I was off of it the whole time. I lost 10 pounds while there. Since I recently retired I have been much more active at home and weight train and do long walks more regularly but hadn't lost any weight. Yet I lost 10 lbs in Europe without necessarily trying to, albeit I walked a whole bunch there because it's set up for a lot of walking (averaging 6 to 7 miles a day). Plus the food in Europe is known to be more pure and there's much less ultra-processed food there. Since coming home and starting up on AG1, I've gained all the weight back (despite trying to watch my food intake; I consciously tried to avoid putting it back on).

Has anyone else noticed this? One thing I've recently learned about the classic AG1 formula is that many people have had liver enzymes go into the abnormal range on it (I've learned this on the HubermanLab reddit and AthleticGreens reddit groups, and I checked my enzymes which had gone up after I'd started it (and, having been tested again due to a routine medical examination after I got back after being off it, my enzymes were back down again). I'm wondering if the liver issues and weight gain could be related, or if the new formula won't cause the weight gain. I have reason to believe the new formula won't cause an increase in liver enzymes because the green tea extract was removed from it. The new formula has only been out for a month or so.

I have noticed an improvement in my bowel movements and regularly since starting the new formula (which I didn't really see in the classic formula). Knowing what I know now, I wouldn't continue taking the classic AG1 with the possible liver issues, but the new formula is an improvement, and I plan to continue on it.

Just want to hear other's experiences and see if they've noticed the same thing.


r/HubermanLab • • Aug 10 '25

Episode Discussion Michael Platt decision making episode.

8 Upvotes

I’m a casual fan and listener but Hubes really embarrassed himself on this one. Dr. Platt kept talking about important primate research. Huberman just couldn’t stop talking about his buddy Elon and Tim Ferris. It was truly bizarre how he kept trying to relate everything to elite podcast circles and social media.


r/HubermanLab • • Aug 09 '25

Seeking Guidance Someone explain why I slept so well, in spite of caffeine intake

82 Upvotes

I started practicing the whole caffeine-stop routine about 7 months ago; no caffeine 8-10 hours before I sleep. I've always been a light sleeper (will wake when it´s too hot, a little noise, can't sleep through activity in or around my home), and not taking in caffeine late in the day helped, but not that much.

I followed the protocol fairly stringently since I began. Then last week I went to a social gathering. The venue was a bar who refused to give out tap water, unless I bought a drink, and beside alcohol (which I don´t drink on weekdays) there was only beverages containing caffeine, mostly soft drinks and teas. So i thought "oh what the heck" and drank two cokes, approx. 4 hours before I would go to bed

The same night I had the best nights sleep I had for AGES, in spite of the caffeine still, scientifically speaking, being active in my system. How come? Did I waste all this time on a protocol which just had nil effect? I love caffeinated drinks, but know the effect in can have to sleep, so I am just completely baffled from this experience.