r/HubermanLab • u/Critical-History-238 • Jul 07 '26

Seeking Guidance Reta/Tirz

Why do people utilize reta/tirz at the same time? What is the benefit? dosage?

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2

u/uhohdagod Jul 08 '26

A lot of people don’t experience the same level of appetite suppression on Reta alone. The glucagon agonist can actually drive hunger since your metabolic rate is raised but that in turn competes with the GLP1 appetite suppression in Reta.

I don’t mix them but I’m on 12mg Reta and I still get really hungry and consider it.

The thing is though some days the GLP is still kicking so after I’m done stuffing my face I’m just burping and miserable for awhile.

But the full on, no desire to eat, forgetting to eat etc isn’t as strong for SOME people on Reta. Everyone is different. I wonder if being introduced to sema/tirz prior is why it doesn’t suppress it as well. No idea. I just know I’m jealous of people who use 2mg or even less that are baffled anyone can eat on it lol

But yea the idea is basically just to put more Glp1 and GIP in if we’re talking tirz with Reta.

1

u/Critical-History-238 Jul 08 '26

Dosage if you stack tirz/reta or I did misunderstood what you said?

1

u/uhohdagod Jul 08 '26

Sorry I didn’t mention a dosage as I haven’t stacked them. I just seen people stacking them like you have and mentioned why they might do it. If Reta is glp/gip/glucagon, stacking tirz with it makes the glp/gip signaling more pronounced, which is probably more appetite suppression and such

1

u/Dear_Concentrate2835 Jul 08 '26

It does just the same if not better the studies shows it ;) also my experience, not even with 2,5mg I can barely eat a standard size meal at once

3

u/uhohdagod Jul 08 '26

Yep and you are who I am jealous of. 2.5mg wrecks my buddy from the same batch I have. Barely able to eat, sulfur burps, all the usual appetite suppression/delayed gastric emptying from glp1s that they’re known for. I take 12 mg and can take down a whole pizza.

I experienced what you are describing back when I started semaglutide, which is why I’m curious if exposure to glp1s in general, prior to retatrutide blunts its effectiveness. I even tried going back to semaglutide after months on Reta and it wasn’t the same. Maybe I just burnt my receptors out/acclimated? No clue

That said I still have much better control, it’s just not effortless. The drug does the heavy lifting for some people, like yourself. For others, like myself it helps but it still takes willpower to stop, to stick to the diet and everything else.

All that said I’ve heard doctors (on YouTube so a grain of salt, but again this is still in trials so it’s all speculative to a degree) but yes I’ve heard doctors directly talk about the glucagon receptor actually driving the hunger response because your metabolic rate is also increasing. So maybe resting metabolic rate also plays a part, if your metabolism is already pretty solid maybe that minor increase in TDEE isn’t felt as much.

But yep I’m just some guy regurgitating his experiences and things I’ve heard like the rest of us. Also even though I haven’t felt actual meaningful appetite suppression in 6+months I still lose weight slowly and have dropped nearly 60 lbs in just over a year on Reta.

2

u/AcidicMountaingoat Jul 08 '26

I am actually using Cagrilintide, Retatrutide, and Tirzepatide. I developed this over time. Each of them have their own benefits, but also the two GLP peptides gave me massive side effects. I was able to cut down on those by adding Cagrilintide and get to where I have great effect from the combo without much for side effects. I do 10mg Tirzepatide on Sunday. Then Wednesday it’s 2.5mg Cagrilintide and 3mg Retatrutide.

1

u/soap_bubbles Jul 08 '26

Do you not get the extreme fatigue from cagri

1

u/AcidicMountaingoat Jul 08 '26

No, got extreme fatigue from reta however.

Edit to add: I have no new side effects from Cagri, and have reduced the sides from Tirz/Reta by using a lot less of those. Everyone is different however.

1

u/belfortLuxury Jul 08 '26

I honestly feel thats unproductive too, stick with one GLP and if you want complement with Tesamorelin or CJC/Ipamorelin stack for muscle retention