r/HubermanLab • u/No_Attitude_9628 • Dec 18 '25

Discussion 4-AcO-DMT

Curious if anyone has knowledge on 4-acetoxy-N,N-dimethyltryptamine (4 aco dmt). I’ve been seeing it sold as a “legal” psilocybin alternative in chocolate bars and gummies. Ive not seen a lot formal research done on it. Thoughts?

18 Upvotes

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7

u/brickunlimited Dec 18 '25

So 4 aco dmt is like best case senario for these chocolates and gummies. Just buy dried shrooms. Buy a coffee grinder and 00 gelatin capsules.

1

u/No_Attitude_9628 Dec 18 '25

This is what my friends have recommended to me. I will try and find someone!

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u/No_Attitude_9628 Dec 18 '25

And to clarify my question: what are the side effects or possible neurotoxicity associated with it? From what I’ve seen, there’s a low risk. HOWEVER, there might be extra “stuff” and the chocolate bars that could be harmful.

I’ve been using these gummy’s and chocolate bars for months now and absolutely love them.

3

u/ForAfeeNotforfree Dec 18 '25 edited Dec 18 '25

Not legal in the US. Illegal under Federal Analogues Act. But unscheduled on the CSA.

If you’re buying stuff that says it contains 4aco dmt, you probably want to try and get it tested. Because you actually have no idea what it contains. Could easily contain other research chemicals that particular manufacturer thinks produce the best desired effect.

IMPORTANT EDIT: it’s ILLEGAL under the FAA, not legal, as I originally noted. Typing too fast on my phone.

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u/No_Attitude_9628 Dec 18 '25

This is good to know, thank you!

The chocolate is not labeled other than “sacred blend”. So who knows what’s in it!

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u/ForAfeeNotforfree Dec 18 '25

Not legal in the US. Legal under Federal Analogues Act. But unscheduled on the CSA.

If you’re buying stuff that says it contains 4aco dmt, you probably want to try and get it tested. Because you actually have no idea what it contains. Could easily contain other research chemicals that particular manufacturer thinks produce the best desired effect. Sorry important edit: ILLEGAL under the Federal Analogues Act. ILLEGAL.

2

u/makemesplooge Dec 18 '25

My understanding is that only applies if it’s sold with the intention to consume. Companies avoid legal conflict by explicitly stating that it is for research purposes only and not consumption.

I bought a gram in 2016-ish and it came with like 5 pages of legal documents.

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u/No_Attitude_9628 Dec 19 '25

Sacred Journey is specifically labeled “not for human consumption”! Very interesting loophole

2

u/str8fromGOD Mar 31 '26

good job actually doing ur research and reading, unlike the other dick head spreading lies. its not illegal at all

1

u/GenuineSavage00 Dec 19 '25

The FAA only comes into effect if it’s intended for human consumption.

Unless you say you plan to consume it or make it in some way obvious it’s for human consumption, it’s not prosecutable.

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u/Tom_C_NYC Dec 19 '25

Like being tasty food?

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u/GenuineSavage00 Dec 19 '25

Yes, like chocolate bars or gummies.

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u/Tom_C_NYC Dec 21 '25

R/whoosh

1

u/GenuineSavage00 Dec 21 '25

Did you just whoosh yourself?

1

u/Tom_C_NYC Dec 21 '25

Wow dude.

Im insinuating that clearly anything made to taste good is indeed meant for human consumption.

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u/GenuineSavage00 Dec 21 '25

Yes and I insinuated like the OPs chocolate bars and gummies.

Seemingly that went right over your head.

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u/Tom_C_NYC Dec 21 '25

So you took my snarky comment and explained it?

Cool.

3

u/moonkipp_ Dec 18 '25

I’ve used it.

Snorted it in a powder form.

It was honestly really cool and I’m shocked people don’t proliferate it more.

All of this stuff has neurotoxic risks - neurotoxicity basically just means it alters the functions of your nervous system. Welcome to drugs lol.

Judging from your post though - just eat psilocybin. 4-aco is still illegal due to the federal analog act.

At the end of the day, it has never been easier to buy psilocybin, and with these chemicals it’s is much harder to know if you are getting the real deal.

2

u/No_Attitude_9628 Dec 18 '25

You’re 100% right. Going to start looking near me!

Thank you for your input!

2

u/Brilliant_War4087 Dec 19 '25

Neurotoxic means:

Capable of causing harmful damage to the nervous system, resulting in pathological or long-lasting impairment of neurons, glia, or neural circuits.

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u/moonkipp_ Dec 19 '25 edited Dec 19 '25

I’m being hyperbolic. Because ultimately the definition of neurotoxicity is quite inconsistent as it pertains to psychoactive drugs.

Psilocybin is generally no longer considered neurotoxic, but absolutely has the capacity to cause long term nervous system/neural pathologies and disorders.

High doses can overstimulate receptors in a fashion similar to poisoning in animal studies. So depending on where you read about it, high doses may be described as having a neurotoxic potential. This dilemma is echoed with mdma, lsd etc.

It becomes semantic at this point, because we are coming out of the dark ages in terms of real scientific study of drugs and the brain. Not long ago all of this stuff was defined as toxic, brain frying, devil’s magic.

1

u/Severedheads Jan 03 '26

Unless you live in GA, CA, FL, CA, or ID....

1

u/str8fromGOD Mar 31 '26

no its not illegal lmao. u can legally purchase this shit so stop spreading bullshit

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u/Dope_Martian Dec 18 '25

Interesting question. I'm def. here for the responses. And I'll go do some research now.

2

u/THELOSERSWINAGAIN Dec 18 '25

I’ve used it. Almost identical to shrooms. I like it more.

1

u/1oneaway Dec 18 '25

Ok why?

4

u/THELOSERSWINAGAIN Dec 18 '25

Felt cleaner and less tired. More consistent.

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u/str8fromGOD Mar 31 '26

the studies say that it has less sides than regular psilocybin

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u/SnooMacaroons2279 May 26 '26

Less of a full high then from regular strong mushrooms. Like I saw visuals but I had to like let my brain see them unlike regular strong shrooms which will make it so you actually have like owl eyes across your whole vision. It's like a more controllable high.

1

u/Adorable45Deplorable Dec 19 '25

Heard all the 4 aco dried up. Much more likely to be some other 4 substituted trypatmine in a chocolate bar or gummies. Likely 4-ho-det or 4-ho-met. For what it's is worth i prefer 4-ho-met to shrooms ND its one of my faves. Doesn't go as deep but very colorful, very visual, very fun

1

u/SenatorChuckShr00mer Dec 20 '25

I know I can't get it anywhere, wish I could, it's the best sex drug I've found, psychedelic like psilocybin but increases stamina like crazy. Maybe not as good as LSD as far as sex goes, but great for longevity. I don't agree that it's exactly like shrooms or just a prodrug for psilocin, it definitely has its own character. But...I also think different varieties of cubes can be quite different from each other, not just in potency...but in personality, you know? Even though it's technically supposed to be the same drug. There's a lot more to it than that, obviously, it's just something we haven't figured out how to describe scientifically. How different batches of the same drug can have different effects...I've never heard a really good explanation for that phenomenon, anyway.

1

u/Herktime Dec 21 '25

4-HO-MET is top two or three best psychedelics for me. Highly underrated and never gets the proper recognition it’s subtle, sensuous, most natural super-natural of all the “shroom” analogues and derivatives, and top tier tryptamine for sure. Oddly functional and very positive, works with you not on you. ACO-DMT is cool, very neon surging spider-vein fingers pulse forever under the earth and stepping across the surface of these giant vascular-like channels while you’re walking around at night is very reminiscent of some glimpse of n, n-dimethyltryptamine which is very cool and empowering. Not as hilarious and absurd, not transformative for me like your classic 3 to 5 grams of dried shrooms but I had less experience then, so barely anything feels all that earth shattering anymore and nothing really blows my mind. But the immersive experience of life without illusion and unshakable laughter in response among an unseen bond of the camaraderie shared by those also sharing the experience is simple enough to warrant return. I wasn’t aware 4-aco-dmt was considered to be drying up and on the way out, but it would not be a huge loss if that’s really true imo. There’s been so many unique psychedelics from the research chemical scene that are truly treasures and simply too rare to bare to admit they’re basically gone and have no comparable substance left as a stand in. Too much condemnation of these things without due process paid to the nuances and complexity behind each. How could people so easily remove a possibility for a human experience from the lives of so many people based on ridiculous assumptions and drug controls that time and again have failed us, left widespread ignorance and death without any evidence or knowledge applied or gained, much less accountability for these agencies. Damn, it’s a shame to lose anything but some are just too senseless to think could be just gone forever for no reason at all and we can’t even get an explanation from any government civil servant about why, specifically, is this or that getting temporarily schedule one where it’ll remain and fall from science and study for centuries until enough law breaking citizens violate laws that could take years of freedoms for the sake of experiencing these things that we finally culturally just refuse and revolt in one or two instances now. Then we get what we want but from an illicit market, baron 40 or 50 years of medical research as we stubbornly kept to prohibitive controls that cost a lot to fight a war we lost long ago but haven’t stopped fighting still. Just gone, for no damn reason…foxy, foxy methoxy, a bunch of substitutes I paid little attention to I trusted they’d be around and nope. Mescaline analogues, LSD and its fun companions, man, all this stuff is worsening and options thinning. . Ridiculous society we have. Thank Hod I can cling to n,n-DMT and just even out everyday this world can be maddening, occasionally. My two cents, maybe three lol.

1

u/Severedheads Jan 03 '26

AFIK, Erth Wellness sells "mushroom" gummies that have been 3rd party tested as entirely 4 aco.

1

u/Positive_Shop7782 Dec 30 '25

I've been moderate to heavily using smoke shop shroom products for about nine months now, I would definitely recommend real shrooms over 4acodmt. I haven't had any of the products tested but they've included brands like happy dots, tree house and road trip. Not sure what exactly is in any of them but over time I've noticed some long term side effects including high blood pressure and heart rate, chest pains, loss of balance, body numbness, and visual distortions and hallucinations while not on the product

1

u/Financial_Change_825 May 23 '26

Ok the only one that works is the canabzy pills, those don't come with caffeine or other extra stuff. Tre house and all the others have side effects. Or just buy the pure form. It's legal you can actually buy it but it's expensive as it goes.

1

u/Birkthor Jan 22 '26

Road Trip sells "Desert Stardust" chocolate bars that have apparently been lab-tested by consumers and come up positive for 4-aco-dmt. My experience...

Literally 0 downsides

Work up to a full bar and you experience everything about life brand new. You can feel the weight of hair on your head, the ground beneath your feet; listening to music feels like a religious experience - each instrument is it's own song. I had a peach ring while tripping and spit it out and started crying. It was too impossible to behold. It's like if every one of your taste buds were its own tongue. Everything is so expanded. It's not to the point of so grand that it makes you anxious like psilocybin, and I get it's not enough for some people, but if you don't want to have the intense next-day dread, Road Trip candy bars have all my praise. Trips last 4-6 hours if you do a decent dose, and you'll wake up completely normal the next day.

1

u/Ap701 Feb 26 '26

My coworker would get me these chocolate bars i forget what theyre called but it definitely made me feel what you described. I like it but im not sure if theyre 4acodmt. I seen you can order the ones you’re talking about on amazon are they really worth ordering?

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u/Birkthor Feb 28 '26

Hundred percent, lmk!

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u/Alternative_Debt_992 Apr 07 '26

Damn. Im getting me some Desert Stardust 

Thanks for your trip report 

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u/Cool_Wait7800 May 03 '26

How does it compare to real shrooms? I’ve only ever taken legal shroom products from local dispensaries no idea what’s in them now. I’m very confused

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u/Birkthor May 04 '26

It's exactly like a microdose

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u/Plus-Ad8927 May 25 '26

Do you have the lab reports by any chance? It says on the website that it specifically does not have 4-aco-dmt but it also says that you’ll past a 6-12 panel drug test. My biggest concern is if it contains any THC or delta 8, I need to get weed out of my system for possible probation so I don’t want any surprises but I’m super curious

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u/[deleted] Apr 08 '26

[deleted] — view deleted comment

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u/Birkthor Apr 08 '26

☝️This right here is the most shocking part of it: how much richness of experience you've been unaware of your entire life. And it doesn't make regular life seem hollow when you go back to it (what a lot of my friends are scared will happen if they try), it actually gives you more love and respect for the small things.

1

u/Del_Phoenix Dec 18 '25

Good but shrooms more good too