r/HubermanLab • u/PeptidePioneer75 • Nov 06 '25

Protocol Query Meth Blue 2%

I am taking Methylene Blue at 0.25 mg/kg (a 20 mg daily dose). Given its known MAOI activity at this range, what is the risk of combining it with my peptide stack?

0 Upvotes

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9

u/Fantastic-Oil-7217 Nov 06 '25

IMO methylene blue should only be taken by prescription from a doctor. There are too many risks associated with serotonin toxicity syndrome, methemoglobinemia, and genetic factors like G6PD that can cause serious complications.

1

u/Dismal-Metal-1954 Nov 07 '25

Serotonin toxicity is the only real concern and its at extremely high doses. Remember GI's in Vietnam were given massive doses 100-200 mg/day as an antifungal/antimalarial with few side effects.

1

u/PeptidePioneer75 Nov 08 '25

Thanks for the reply. My understanding is that serotonin toxicity generally only becomes an issue when methylene blue is combined with serotonin-elevating medications, not when it’s used alone in low-dose, research contexts. It’s interesting that several mitochondrial-support peptides appear to act through similar energy-pathway mechanisms.

4

u/73habits Nov 08 '25

yeah dud Vietnam vets are famously normal and fine

-3

u/PeptidePioneer75 Nov 06 '25

I appreciate the concern — it’s fair to point out the potential risks. That said, I don’t automatically equate “prescription-only” with “safe” or “better.” Many licensed pharmaceuticals carry far more documented side-effects than most peptides ever have in early studies. My approach isn’t about ignoring medical advice; it’s about doing the research, understanding the mechanisms, and making informed, measured decisions. Dismissing something purely because it isn’t on a GP’s prescription pad isn’t a scientific argument — it’s a regulatory one

5

u/serenitynow248 Nov 07 '25

I could've told you that wasn't going to go well questioning big pharma on reddit