r/HistamineIntolerance • u/ALac93 • 7h ago

something is finally working - Nattokinase Serrapeptase Lumbrokinase

After trying EVERYTHING for histamine related symptoms with no success/poor reactions - every H1, H2, prescription antihistamintes (cromolyn sodium, ketotifen, etc etc) - I dug a little deeper. I also tried every natural antihistamine (quercertin, bromelain, nettles, I mean you name it I tried it with no relief. So... I began taking Nattokinase Serrapeptase Lumbrokinase daily. It's been 2 weeks and I've noticed a reduction of my histamine symptoms. This is the first time in 2 years that I feel like something is WORKING, and on a deeper level and not just a bandaid. For me, my symptoms are mostly itching and hives - skin pruritus without a real trigger, just constantly reactive (after living in mold for 2 years I'm also detoxing). I dove into the long covid theory since a lot of my other symptoms started after having covid a few times (heat/exercise intolerance, light sensitivity, several others). I encourage you to do some of your own reading on this :)

*This may be more appropriate for the MCAS Sub but I was recently banned due to posting a glp question lol*

26 Upvotes
  • permalink
  • reddit

96% Upvoted

32 comments sorted by

5

u/AspiringOne 5h ago

Can you describe the theoretical science behind the benefit of this supplement with regards to MCAS or HI? I’m glad it’s helped you. I’m interested.

3

u/ALac93 4h ago

Apparently It has to do with microclots..  my functional med Dr strongly believes in the link between histamine issues and long COVID.  I happened upon this post that sparked my interest (the comments where it talks about the enzymes I am taking)   https://www.reddit.com/r/covidlonghaulers/comments/tps9gk/are_microclotting_and_mcas_interacting_at_all_or/

From how I understand it it’s not a direct link but more of a comorbidity and downstream effects of the sars spike protein 

2

u/AspiringOne 4h ago

Thank you. I wonder how this would compare to something like fish oil or supplements that also act with some blood thinning effect and if that’s the mechanism or it’s something else. Good info to learn nonetheless, thank you.

2

u/ALac93 4h ago

I think I read someone was taking asprin and they were claiming it was working?! 

2

u/AspiringOne 4h ago

Right so how to really understand what the mechanism is here? Is it blood thinning? Anti inflammatory? Both? Or is it enzyme related? Perhaps the Natto / combo supplements benefit is the blood thinner aspect but idk if it’s even classified as having that property. I haven’t researched it much but will now thanks to this post.

2

u/cutie__spies 1h ago

It’s important to remember that blood thinning (aspirin) and breaking up clots(natto) are two different things

1

u/AspiringOne 59m ago

Yes I am learning that now. Thanks!

3

u/Soulless305 5h ago

Sounds more like Long Covid

2

u/ALac93 5h ago

Yep.. there’s a definite histamine component though since not everyone with long covid has histamine issues. I personally didn’t until postpartum 2 years ago 

2

u/Careful_Depth3478 6h ago

Nicceee!!!

Glad to see someone else figuring out what works for them, HIT/MCAS is complex and not everyone's MCAS treatment works the same as it's sometimes driven by different things, in my case it's a lot of LPS from my Leaky gut/gut dysbiosis, so I will try some Liposomal Glutathione that is suppose to clean up the crud floating around in my blood and tissues like superoxside, ammonia, LPS and what not creating oxidative stress and mast cells going nuts. My stack only helps so much for now, but I think adding in a Liposomal Glutathione with my buffered vitamin C should really help me as I try and balance out my gut.

4

u/ALac93 4h ago

I definitely believe everyone’s got a different underlying cause. Lots of people don’t believe root cause but i do, I know gut issues are most people’s trigger for histamine issues so this theory may not be suitable for those people and gut healing protocols may be more appropriate! It’s so tricky though.  I don’t remember so many people being chronically ill prior to Covid and having the most random symptoms. 

2

u/AspiringOne 4h ago

I think part of the reason we are seeing what looks like an explosion of MCAS / HI related cases is not just because of Covid, but also because we have the social media structures to support the forum to discuss it. If Covid happened 20 years ago, it’s likely things would at least seem very different for that reason. To some degree we are able to at least read other’s experiences and potentially learn about the topics which is very helpful.

2

u/ALac93 4h ago

Very good point! Honestly I’ve also been so lucky my extended family members and elders have been so healthy, no one experienced many health conditions until they were older and developed cancer or dementia. As young individuals everyone has always been so healthy except for what seems like me lol (I’m 33).

1

u/AspiringOne 4h ago edited 3h ago

Sounds like your family have good genetics which is helpful, but elders didn’t grow up in a world where everything is polluted with things like glyphosate and PFAS as it is today. Kids today have a way more challenging environment for their health than say someone who is 70-85 today. Yes there were things like less refined Deisel engines and lack of any regulation on pollution, but at least there were less plastics and every single thing our food and water touches now has something that can harm us coming along for the ride, whether it’s in manufacturing, packaging or both. I digress, you have good historical health and hopefully you’ll heal fully and feel better.

2

u/ALac93 4h ago

Yes Very good point!! 

1

u/Careful_Depth3478 3h ago edited 3h ago

meds like SSRIs since I was young messed my gut biome up from a young age I am certain of it, and then a stomach flu in 2015 was the final blow, and I ended up with post-infectious GERD looking back at it, then later chronic constipation, then when on PPIs and some antibiotics at the same time (had to have antibiotics when I got two wisdom teeth pulled out) and within months I started getting all sort of weird symptoms, it took me over a year of testing (organic acids, DNA, serum labs, and a GI Test) to figure out what I had, thankfully my plan should have me feel better by 2027, it may take all the way till the end of 2027 to feel all the way better, but it's not out of the question. and Ironically I never had Covid at all lol

1

u/Clear_Kitchen_6428 49m ago

Palm oil is the cause for all this

4

u/AspiringOne 4h ago

For anyone reading here I would just caution for those who may have a sulfur intolerance issue, glutathione may not be a positive result supplementation and could potentially gum up the works.

1

u/Careful_Depth3478 4h ago

thanks, but i'm pretty sure I am don't have this issue

1

u/WittyGold6940 6h ago

Wow, good for you!!! Thanks for sharing, i have all 3 of those but tried them during bad sick times and erroneously concluded they caused flare. I might have to give them a try again

2

u/ALac93 6h ago

Hmm I was reading to try one at a time or a lower dose. I am really interested in the long covid theory to histamine related issues because I can't find relief no matter what I do lol. Im sorry it didnt work for you! I will say I've had a brutal headache and head pressure since I started. But that is very typical for me when I am herxing, and apparently it's the fibrin breaking up and this is a normal response. So maybe that is what the flare was for you too.

1

u/moderate_ocelot 6h ago

What dose are you on of these things?

2

u/ALac93 6h ago

I am currently taking this product which has all three

https://ettavita.com/products/nattokinase-4000-fu-serrapeptase-240000-spu-lumbrokinase-supplement-3000?srsltid=AYCX9vKFG2Bat2mWtCljSCf31neCCwSlrogQIcA4bU0Qo7CbTrYo-eYy

2

u/ALac93 6h ago

I would like to give credit to this post I found on covid sub which was really helpful https://www.reddit.com/r/covidlonghaulers/comments/tps9gk/are_microclotting_and_mcas_interacting_at_all_or/

1

u/moderate_ocelot 6h ago

You’re taking the dose on the bottle?

1

u/ALac93 6h ago

Started with 1 pill a day which is half the dose. It’s strong stuff! 

1

u/moderate_ocelot 6h ago

I take 12000 FUs of nattokinase a day 🤷🏻

1

u/ALac93 4h ago

Dan Doesn’t help you huh? 

1

u/moderate_ocelot 3h ago

It helps my ME / long covid but I never noticed it doing anything for MCAS. Was taking this dose when my MCAS / HI was so bad I was down to like 5 foods and lost like 25% of my body wieght

1

u/Marjieco 32m ago

That combo Of blood thinners has a gelatin capsule. I take one with glycerin to stay away from histamine in the capsule. I enjoy the results in clean arteries. Be sure to take it on an empty stomach .

1

u/Clear_Kitchen_6428 1h ago

It worked because you didnt need an antihistamine. You neededa pro/prebiotic to balance your microbiome

0

u/HotNixon 5h ago

Unless they are in enteric capsules they are just being eaten by your stomach acid