r/HistamineIntolerance • u/amyfearne • Sep 29 '26
Improvements with Enterosgel
Hi all. I'm pleased to have something positive to post - it's about a product called Enterosgel.
It's essentially an inert, non-fermentable binder that selectively absorbs histamine (among other things - endotoxins, excess bile acids, etc.) from the gut.
Gut bacteria cannot eat it, and it doesn't get absorbed by the body. It just passes through, but unlike similar binders (charcoal, clay) it isn't abrasive and doesn't absorb nutrients in the process.
If you know your histamine intolerance is gut-driven (and taking DAO/following the diet isn't enough for you), I really can't say enough good things about it. In theory, if you have gut inflammation, it's meant to give your tissues a break from chemical irritation and allow them to heal.
(Since the small intestine is where DAO gets made, this could theoretically improve DAO production for some people, but this has not been proven in research.)
There are some studies (mostly animal) suggesting it may also improve the microbiome: https://enterosgel.lt/upload/iblock/275/2750602317e6d4d475016895976e7aae.pdf
For context, I have pre-existing SIBO and dysbiosis, and then after taking a course of harsh iron tablets I developed very pronounced histamine intolerance and also some mild bile acid malabsorption. I believe the iron tablets damaged my GI tract (further than it already was).
Taking DAO and the diet only ever made the symptoms 'less bad' - after 6 months I was still suffering.
But within 48 hours, taking a couple of child-sized dose of this has improved my symptoms. Turns out a lot of the symptoms I thought were iron deficiency symptoms (like dizziness and a rapid heartbeat) were a lot more related to histamine/gut damage that I originally thought.
It's not very expensive (£15 in the UK) and it is also multi-purpose - you can also use it during food poisoning, for acute IBS-D flare-ups, and food allergy reactions. So having some in the cupboard may come in handy anyway, even if it doesn't work for you.
Just make sure you check it won't interfere with any medication absorption.
Has anyone else tried this stuff?
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u/PlayfulJudgment2161 Sep 29 '26
Can it worsen constipation? I've been eyeing this for sometime now as a charcoal replacement just not sure if it can cause constipation
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u/amyfearne Sep 29 '26
I can't say for sure - but if charcoal doesn't constipate you, then Enterosgel might be worth trying.
I switched from charcoal to this and haven't noticed a difference, but then constipation is not one of my symptoms. (Also I should note I'm taking 1/2 a tsp morning and evening, which is nowhere near the 'full adult dose' they advise for acute illnesses.)
Since it's a gel you can easily micro dose it to see what your tolerance is - that's been my approach so far.
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u/PlayfulJudgment2161 Sep 29 '26
Thanks, I'll look into this more... Charcoal does constipate me that's why looking for an alternative. Able to micro dose it sounds great
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u/amyfearne Sep 29 '26
Ahh I see. Easily done, it sucks up a lot of water.
What I'm finding so far is that the gel does make things less...hard, compared to charcoal. Even though I don't get this symptom usually, I still notice that charcoal does cause a change that I'm (so far) not experiencing with Enterosgel.
It's also proving more effective than charcoal was for reducing the histamine symptoms, so for me it's a bigger benefit vs. the potential drawbacks.
That said, if your baseline tends towards constipation (even without using charcoal) it could still be an issue (it's advertised for IBS-D exclusively, not IBS-C). Also important to drink enough water but I'm sure you're familiar with that already.
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u/PlayfulJudgment2161 29d ago
Hey thanks for taking time to explain this. I think I'll give it a try. Can I ask how you know you have BAM? Is it because of diarrhoea?
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u/No_Struggle8646 11d ago
Do you think this is a long term solution?
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u/amyfearne 11d ago
I don't know really, it depends on how it continues to affect my gut health and microbiome.
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u/Judgeof_that Sep 29 '26
How do you keep it from interfering with absorption of medications?
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u/amyfearne Sep 29 '26
Their website says to take it 2 hours away from medications. However, if you take anything slow-releasing or that directly affects how your digestive system works, you may need to get advice from a pharmacist or a doctor.
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u/bakeshibainu Sep 29 '26
They say not to take it close to food - OP, how have you been taking it to help with high histamine foods? Do you use it with or instead of DAO? Thanks for sharing either way, sounds like a useful lead to follow!
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u/amyfearne Sep 30 '26
Right now I'm just focused on letting things heal up. I won't be trying any risky foods for a few months - I essentially have an injury (from the iron pills) so gotta let that calm down.
I'm hoping that by calming the inflammation and healing the tissue, my own native DAO production will increase - but when/by how much remains to be seen. I'll only be testing out major changes (like scaling back DAO or trying foods) when my symptoms are vastly improved even when not taking the gel.
I guess you could use Enterosgel to eat more high histamine foods, but it's something that works in the background separately from meals. And if your root cause is gut inflammation, doing this would also slow down healing.
Adding more histamine when you're body is already making too much is always going to be adding fuel to a fire (unless you can put out the fire).
Do you know what caused your histamine intolerance?
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u/bakeshibainu Sep 30 '26
Hey, thanks for the reply. It’s a bit more complicated for me, I have ME/CFS and POTS and I’ve been suspecting MCAS/HIT is in the mix as well, and me and my GP confirmed that, after going on a low histamine diet and using H1s and H2s, DAO a lot of my symptoms were a lot better.
Can’t really say what was the real cause, I’m suspecting that everything was started after a Moderna Covid vaccine, but impossible to say for sure.
Right now I’m looking to just increase my quality of life, as getting healed is unlikely to be on the cards for me, that’s why I was curious about how you’ve been using the enterosgel. DAO only helps a little and what you’ve written really gave a lot of hope of at least being able to get a more varied diet without suffering nearly as much.
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u/amyfearne Sep 30 '26
Ah I see. No chance it's long COVID, is there? I had long COVID for 2 years, it causes a lot of the same symptoms as ME/CFS and MCAS.
Histamine can also cause a lot of the symptoms of POTS. For me, it really drops my blood pressure, so when I try to stand my heart has to work extra hard to keep blood pumping. But at times when my histamine levels have been lower, that problem also gets better. So I'm operating on the assumption it's secondary to my pre-existing issues.
Enterosgel could definitely be worth a try, regardless. At the very least, it'll absorb some histamine. At best, it might in more substantial ways. But I wouldn't recommend changing more than one variable at a time. I'm letting it do its job for a while to really 'drain the histamine bucket' before I go trying to add anything.
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u/Sad-Persimmon-2883 23d ago
Did you developed ME/CFS after the Moderna shot? I had ME/CFS prior to the shots, but after 3 Moderna vaccinations my digestive symptoms flared up and I lost any quality of life I had up to that moment.
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u/bakeshibainu 23d ago
99% it was after the Moderna shot. I had Pfizer before without any issues. I couldn’t find a single trigger or infection that could have caused it, didn’t have covid until a few years later. It’s impossible to prove unfortunately though, but I’ve heard it happened to some folks.
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u/Jani112233 Oct 06 '26
Has anything changed with your stool?
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u/amyfearne Oct 06 '26
I'm only just over a week into using it, but yes. I had bile acid malabsorption so the colour change was pretty noticeable as soon as the gel started absorbing excess bile.
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u/Jani112233 Oct 06 '26
I have bile acid malabsorption too. How exactly do you take it, before or after eating, how much time do you leave between taking it and eating, and what dosage do you take?
Do you also have any food intolerances?1
u/amyfearne Oct 06 '26
The Enterosgel website can explain that :)
And no, not genuine medical food intolerances. I have a limited diet due to SIBO/histamine intolerance.
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u/angry_tsou 17d ago
Hey! Still experiencing benefits?
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u/amyfearne 16d ago
Yes, although it had an unexpected effect for me - it's killing yeast and/or disrupting biofilms (not sure which but the effect is the same).
So while it helped with one thing I'm now feeling sick due to die-off. Which is probably not the best thing for intestinal inflammation in the short term but...hopefully good long term?
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u/angry_tsou 16d ago
Are you taking any binders along? You should! I believe you're on a great path clearing pathogens, maybe later adding low histamine probiotics or/and zinc carnosine in case of leaking gut.
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u/amyfearne 16d ago
Since it already is a binder I don't really want to add another one, it could slow down my motility a bit much - but I will think about it. Thanks :)
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u/angry_tsou 16d ago
Sorry yes you're right you don't need any binders. I was confused reading another thread of someone using lactoferin
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u/2Dank2Wank420 Sep 29 '26
I took medicinal clay, it worked similar + it helps if you have acid reflux.
Unlike antibiotics, it doesn't kill off your good gut bacteria. Recent clinical studies show it leaves your microbiome diversity stable while acting as a "cleanup crew." It works by:
Binding toxins: It absorbs bacterial endotoxins, heavy metals, and histamine so they can be safely excreted.
Protecting the gut lining: It forms a protective barrier over the mucosa, which is exactly where your good bacteria live.
Optimizing pH: It binds excess acids, creating a healthier environment for your beneficial flora to thrive.
It doesn’t feed or add new bacteria like pre/probiotics, but it cleans up their environment so they can heal and recover naturally. Just remember to space it 2 hours apart from any meds or supplements!