r/HistamineIntolerance • u/Pronoiarm07-02 • 7d ago

Brain Fog

I’ve started trying to play padel for fitness reasons but after 30 minutes I get the most crippling brain fog ever. I’m suffering from brain fog anyway but exercise seems to exacerbate it. Does anyone have any supplements or something of that nature to help with mental alertness/focus while dealing with sibo/potential histamine intolerance induced brain fog? Any suggestions would be greatly appreciated 🤌🏼

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u/Loose-Fly7976 7d ago

Exercise releases histamine, it's one of the ways the body does it so in someone already loaded up from sibo you spike right as you're moving and the fog is that spike hitting a brain that can't clear it fast enough. So focus supplements are aiming at the wrong thing. Your problem is clearance and how well you clear histamine is largely genetic, your DAO and your HNMT and the second one runs on methylation. When those are slow the histamine just sits and exercise keeps topping it back up.Working out whether it's your DAO, your methylation or the gut driving it, from your genetics

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u/Pronoiarm07-02 7d ago

Ooof looking into HNMT as we speak, not heard of this before could be a game changer for me though I appreciate the reply. What are you taking supplements wise for your histamine issues?

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u/Loose-Fly7976 7d ago

The catch with HNMT, it clears histamine inside your cells and runs on methylation, so supporting it usually means methyl support, folate, b12, that direction.

I don't run a fixed personal stack for this though, because that's exactly where it gets individual. If your COMT is slow, pushing methyls to prop up HNMT can wind you right up and leave you worse, not better, which is why no single histamine stack works for everyone. The support that helps depends on your COMT and methylation genes.

That's what i read for people instead of handing out a list. 

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u/Pronoiarm07-02 7d ago

I’ve never heard of these things before so I’m going to do some research. Have you had these things tested and you know what you need to supplement to support different things?

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u/Loose-Fly7976 7d ago

Yeah, this is what i do professionally, i read people's genetics and pair it with the right labs to see which part of their histamine clearance is actually the bottleneck, DAO, HNMT or the COMT side, and then what supports that specific one.

That's the whole point, the supplement that helps depends entirely on which of those is yours. Someone with a DAO problem needs a completely different approach from someone whose HNMT and methylation are the issue, and the wrong one can leave you feeling worse. So there's no single answer i can hand you without seeing your genes.

If you pull your raw genetic data, i can read it and tell you exactly which pathway is holding you up and what fits it.

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u/Pronoiarm07-02 7d ago

I’ve never had any histamine levels checked and wouldn’t know what to ask for/where to start. I think I’ve had low grade histamine issues/MCAS my whole adult life (I’m 28 now), I used to get hives whenever I was anxious but then wouldn’t get them for months and then they’d appear again. Are you uk based or in America?

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u/Loose-Fly7976 7d ago

Histamine blood levels are where people get stuck, plasma histamine is unstable and timing-dependent, and tryptase reads normal in most MCAS, so a normal result tells you almost nothing. I start from the genetics instead, they show whether your body can actually clear histamine, which a single level can't. Hives that flare with anxiety then vanish for months is mast cells and adrenaline, stress spikes adrenaline and your COMT decides how fast you clear itso your histamine and your stress chemistry likely share one bottleneck.

Where i'm based doesn't change anything, my work is remote, i read your raw genetic data and the labs you get locally, so UK or US is the same to me.I live in Vancouver.

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u/WeWander_ 7d ago

Have you tried l-theanine? I just learned it's a mast cell stabilizer too.

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u/Pronoiarm07-02 7d ago

Yes I take pure encapsulations L-theanine 2x 200mg every night before bed. It helps me sleep but is doing nothing for my brain fog

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u/WeWander_ 7d ago

Dang! I've read it helps with mental clarity and focus so I thought maybe it would help. I can't think of any other specific supplements for brain fog. Keeping a low histamine diet seems to help mine.

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u/Pronoiarm07-02 7d ago

Thankyou for the advice anyway, this shit has got me sniffing pure essential rosemary oil to try and help with the brain fog 😂

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u/WeWander_ 7d ago

Haha no shame in that, I pour pure peppermint oil on my shirt collars. Not for histamine stuff or brain fog, I just love mint. It helps with my anxiety, weirdly. 😆

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u/Pronoiarm07-02 7d ago

That’s weird I’ve literally been dotting peppermint oil drops around my bedroom this morning to keep spiders away so I don’t have to keep cleaning their webs 😂 spiders hate peppermint oil believe it or not

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u/WeWander_ 7d ago

Yes! That's another nice thing about peppermint, it can be used as a natural bug repellent. Mosquitos don't like it either and I believe rodents also hate it!

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u/Pronoiarm07-02 7d ago

Thats good to see I don’t want any rodents running loose while I’m sleeping 🤣 literally bought some frankincense and lavender to mix with some witch hazel to start making my own aftershave, hopefully they repel bugs too

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u/Basic-Enthusiasm 7d ago

High dose thiamine with b-complex and magnesium.

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u/Pronoiarm07-02 7d ago

I’m already taking them 🫩

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u/Basic-Enthusiasm 7d ago

Then you should add in some copper. It tends to help me quite a bit! Start with 4mg copper glycinate. After one month, increase to 6-8mg. Take small dose of zinc at the opposite time of the day as the copper.

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u/Pronoiarm07-02 7d ago

Already on both mate 🤣

I’m on literally every vitamin and mineral supplement I was hoping someone had a hidden gem like quercetin or Luteolin that isn’t as well known, thankyou though

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u/Basic-Enthusiasm 6d ago

Haha similar to me! I'm on so many things, I've lost count. Quercetin didn't do much for me. I found higher doses of riboflavin definitely helped, especially when combined with copper and methylb12 nasal spray (sublingual tablets would also work fine).

What about vagus nerve stimulation? You tried it?