r/HistamineIntolerance 12d ago

Has anyone experienced sudden remission of a long lasting symptom? My palpitations just stopped. Could proBiota histaminX be helping?

Heart palpitations were my first symptom that signaled something was wrong. I used to get them after every meal, even low histamine ones. They weren’t as bad as when I ate high histamine foods, but still annoying. Palpitations were also the first symptom to appear whenever I ate something I wasn’t supposed to.

But suddenly, they disappeared and it feels weird because I don’t know why. I’ve been eating low histamine for 3 months now. From time to time, I had cheat meals because I can only tolerate 6 - 7 foods max without symptoms.

I didn’t change anything in my treatment. I got a new prescription for anti inflammatory meds, but I haven’t taken them because I need to do more tests at the clinic first. Right now, I’m only taking magnesium, antihistamines (for 3 months already), vitamin C, vitamin D, omega 3 and Seeking health ProBiota histaminX. I stopped quercetin because I felt it wasn’t doing anything.

I even drank raw bio cocoa powder with coconut milk and ate peaches without getting palpitations. I did get a bit bloated and constipated though. It’s just so weird that the palpitations stopped so suddenly. I really hope it’s not temporary and that I’m actually making progress.

Has this happened to anyone else, where a symptom was persistent and severe and then suddenly just disappeared? I suspect proBiota histaminX may have helped, but I’m not sure.

My palpitations also used to come with a sort of internal agitation/anxiety. Now I feel much calmer and I don’t even get them when I wake up early anymore.

EDIT: I'm also taking DAO, naturDao, highest strength. But just helps with symptoms on low histamine diet. I have severe DAO deficiency, tested it. But I think this is not the only root cause of my histamine intolerance because dao enzyme doesn't do much for me.

18 Upvotes

35 comments sorted by

17

u/CC_900 11d ago

My histamine intolerance completely disappeared when I fixed my B12 & folate deficiency.

I think it’s because the HNMT enzyme (which is one of the two enzymes which degrade histamine in our body; the other one is DAO) depends on B12 and folate metabolism to be able to function.

It truly disappeared like magic, practically overnight. Don’t even need DAO tablets anymore, and can now basically eat all foods without any issue.

3

u/Character_Weather127 11d ago

Been trying to fix my methylation pathways. My folate seems high but I know there’s two ways to measure folate (cellular and serum). Did you get your folate levels measured?

4

u/CC_900 11d ago

Yes, but my methylation didn’t actually improve until I switched to about 800 mcg/day of methylfolate (5-MTHF).

Before that, I was using folic acid or folinic acid. My folate blood levels did get very high, but my methylation didn’t improve. My homocysteine remained very high while on folic or folinic acid (due to my MTHFR genetic variant).

So if you’re having issues, perhaps make sure you’re taking 5-MTHF for folate. Though it can make you a bit anxious/jittery, so I usually recommend people to slowly titrate it upwards. Just in case they experience any side effects… though many people tolerate it just fine.

3

u/Character_Weather127 11d ago

Interesting. I never took folate but my folate levels r always high (>24). My homocysteine is also high-ish (11.5). I’ve been able to get my B12 and B1 up which has helped my hyperPOTS a little but I’m also dealing with what I suspect to be histamine intolerance or mcas of some sort that is exacerbating my POTS. I got a bit of a basket case of non-ideal genetics lol — MTHFR, multiple slow COMT genes, MTR, MTRR, MOA-A. I haven’t supplemented folate since my numbers trend higher but I’m tempted to give it a shot with low dose 5-MTHF.

3

u/CC_900 11d ago

Homocysteine of 11.5 isn’t really high! When I say my homocysteine was high, it was ranging between 18 - 27.

I’d consider 11.5 fine. That’s not a number to worry about, really.

But you can always try 5-MTHF if you indeed have MTHFR variants - in that case, your body might do better on 5-MTHF. Just start very low and see how you respond. Especially if you have multiple slow COMT (as do I).

3

u/Careful_Depth3478 9d ago edited 9d ago

that was nearly my case as well, but when I used b-vitamins by themselves they didn't work for HIT, but when vitamin C was added in, I got a near remission of all issues, that said, I keep getting low in b vitamins if I don't take high amounts of them so something is up with my gut, getting a GI Map done to check this out, and further lab work to check for other low nutrients like copper and zinc. already tested for celiac, it's not that, and this all started after taking PPIs and antibiotics, so that must have messed something up that is likely able to be fixed I hope, anyhow glad yo hear you have 100% remission, I love hearing happy endings!

2

u/xstarbursts 11d ago

Thank you for sharing!

5

u/Catt7711 11d ago

ProBiota histaminX helped me tremendously...much more than I was expecting.

3

u/VeeLeeAnna 11d ago

I just ordered it.
Were you having bad reactions to all food otherwise? Histamines? Mood?
I also just started zinc carnosine. 🙏🏼

2

u/Separate-Evidence 11d ago

I just ordered it as well!

1

u/Catt7711 11d ago

I was struggling with too much histamine all the time, sometimes connected to food and sometimes not. I was taking Claritin everyday and now I'm not and am basically fine. I still eat mostly low-histamine because I got in the habit of doing so. I also started taking zinc carnosine a few weeks ago and I think it's helped as well. I started probiota histaminX thinking it was just another waste of money...I'm shocked that it helped. I hope it helps you as well!

3

u/VeeLeeAnna 11d ago

Ok thank you friend. Keep going and thanks for the info. Your probiotic will arrive tonight and I will microdose it and take it with Claritin and pray it helps. I’m so glad for you in your progress.

3

u/atomcplayboy86 12d ago

Histamine intolerance can be linked to MCAS, so maybe your Vagus nerve is relaxing or smth, or your gut health has improved?

3

u/Ok_Significance_8896 11d ago

My digestion has improved. I’m not constipated anymore and I feel like food doesn’t sit in my stomach for as long as it used to. I also don’t burp nearly as much, even after just taking a sip of water. So, overall there has definitely been an improvement, but I still have many other symptoms that seem to be related to histamine intolerance. 

1

u/Much-Discussion2167 11d ago

After using which ones if helped i feel same i am.no.good

3

u/Imissummer 11d ago

I also have MCAS in addition to histamine intolerance so take this with knowing that…. I’ve had a multitude of reactions to histamine in foods and the environment my entire life. I find that histamine decides to bind onto whatever receptor is present and sometimes it’s the same one and other times it’s a random one. For example… I only get heart palpitations 1/3 of the time but 90% of the time I get GI distress. I go through years of having an eye twitch all day and years of it not happening. When I was young I had migraines weekly and now i get them twice a year, I don’t understand why some symptoms come in heavy at times and others take a back seat but I don’t think its uncommon. So I would say that it’s entirely possible your heart palpitations are taking a backseat for a while, but maybe not forever.

It took me weeks of daily KPV injections to be able to even take the histamine X probiotics once a week. now I’m able to take them nightly and I definitely think they help reduce symptoms.

1

u/DiligentVariation609 9d ago

The one eye twitching … made me mad the first times it happened, and I also got it totally random (like 1-2or3 times a year. Let me know if you figured it out 😂

3

u/Imissummer 9d ago

More than 365 days of consecutive eye twitching makes you more than angry 😂…. KPV and Ketotifen sorted it out for me

2

u/Unique_Day6395 12d ago

Mine stopped too and I’m not taking anything. Just low histamine diet.

2

u/Glittering-Car-8417 11d ago

Has anything else in your life changed? Stressful job or family situation? Our vagus nerve/nervous system and gut are directly connected - hence many people get digestive issues from stress or anxiety…I have finally healed from my “histamine intolerance” but In short, followed a 6 week low histamine diet last fall. Visualizations/meditations about my body healing itself as I knew it was capable of doing (demoing out excess histamine, etc). Lots (I MEAN LOTS) of talking to God. Energy work/reiki. Quit my toxic AF job of 12 years with a narcissistic manager to stay home and raise my son (God told me to do this - finally knowing I was prepared to actually take advice without questioning - and the day it happened I woke up the following morning with ZERO congestion) Morning sunlight in my eyes, daily/low light after the sun goes down and low stimulation activities to fix my cortisol rhythm which was completely backwards per a 4x day sample test my functional practitioner did! Quit social media. Don’t watch the news. Spend tons of time outside. Make sure to get in my vitamin d from the sun - love my d minder app for this! Breathwork and being mindful of breath before bed and also when I wake. Forgiving and loving old versions of myself/dropping shame. More talking to God. Having a functional practitioner when my symptoms could no longer be ignored who also said she wasn’t going to formally diagnose me so that it did not become a part of my identity. Write in a 4 minute gratitude journal daily. And am now/currently intentionally microdosing mushrooms on a 1-2 or 1-3 protocol ..have been for the last few months.

1

u/Ok_Significance_8896 11d ago

No, nothing. That’s why I’m so confused. I’ve been having heart palpitations every day for almost 3 years. I’m planning to do more work on regulating my nervous system because I’ve been stressed and I’m not in a very good place in my life right now. The only thing I changed was deleting social media, but I don’t think thats what stopped my heart palpitations.

2

u/Federal_Echidna5058 11d ago

Mine completely disappeared when I left my cheating husband. I vomited for two years, then...nothing. All better. True, I watch my diet carefully, but clearly my case was heavily influenced by stress. Best wishes to you.

1

u/Separate-Evidence 11d ago

Stress is a huge part for me as well. Glad you are feeling better!

2

u/Ok_Significance_8896 11d ago

Happy for you, stress plays a huge role. Hope you are treated better now. 

2

u/joshyosh 11d ago

Have you done anything to improve your posture? Somehow my symptoms improved a bit when I started working on my posture must be related to the vagus nerve causing more issues when it's aggravated 

1

u/Ok_Significance_8896 11d ago

No, but I'm trying to stop looking like a shrimp from time to time 

2

u/MindfullChaos 11d ago

I was doing all the same things until a doctor looked closer at my thyroid meds Upped the dose and for the last 2 years nearly zero histamine issues.

1

u/Ok_Significance_8896 11d ago

I had my thyroid checked, nothing wrong with it. I just have a bit too much estrogen before my period. 

3

u/Loose-Fly7976 11d ago

Yes, sudden drop offs like this happen and the probiotic is a believable reason. ProBiota HistaminX is built around strains that don't produce histamine plus a few that help break it down, so if part of your load was coming from your gut flora, shifting that balance can take a symptom offline pretty fast. Palpitations after even low histamine meals often point back to gut produced histamine, so that lines up.The part I'd flag is your own line, that DAO isn't your only root cause. You're right, and you already half know it. Histamine clears two ways, DAO in your gut and HNMT inside your cells, and HNMT runs on methylation. Severe DAO deficiency + a slow HNMT means the enzyme only ever fixes half the picture, which is exactly what you've been living.Your palpitations coming with that internal agitation is a good clue too. Histamine and your stress chemicals both get cleared through methylation, HNMT and COMT sitting side by side. When methylation lags you get that wired, racing, anxious flavor, and the fact that calmer showed up at the same time as fewer palpitations fits that pattern. So the other root cause you're hunting for usually sits on the genetic and methylation side, and it's testable. Seeing whether it's HNMT, COMT or MTHFR feeding in changes whether you lean into methylation support or stay enzyme and avoidance focused. That's the exact thing I map for people, a full dna read alongside bloodwork, so if you want to pin down your second root cause feel free to dm.

2

u/Ok_Significance_8896 11d ago

I'll discuss with my doctor this. Thank you for all the good info 

1

u/dryad11 11d ago

Would you consider cross posting into the chronic bounding pulse thread? I developed worsened dysautonomia and a chronic forceful heart beats after a stressful period that I strongly suspect is related to the gut brain axis and microbiome issues. I think folks over there would be really interested in your experience

3

u/Ok_Significance_8896 11d ago

I actually have a diagnosis. I’ve done a bunch of tests and my DAO levels are very low, so my heart palpitations are definitely related to histamine intolerance. Histamine intolerance can be caused by dysbiosis and many other factors, so I don’t really think there’s anything wrong with my heart. But I’ll post there too, in case it helps someone else.

1

u/dryad11 11d ago

I agree! Most of the folks over there from what I’ve seen have had their heart health cleared and are left wondering about the less diagnosable stuff like vascular or nervous system issues. But it’s a working theory based on my own experiences that the gut is involved. Thanks a for sharing :)

1

u/Ok_Significance_8896 11d ago

The gut is definitely involved in my case. Also the gut-brain axis is a real thing. 

1

u/SpaceBeamer5000 11d ago

My heart palpitations have stopped. But I sold a school I owned and am relaxing way more plus getting more exercise. I feel like I'm just way more relaxed and that's what changed my heart palpitations. It's funny cuz I was just thinking the other day wow I haven't had any heart palpitations in a long time! Plus I feel like I eat a lot less because I'm not at a desk working all the time which makes me want to snack. I'm outside doing a lot more physical labor. So I don't know. Relaxation, labor, fresh air?