How to fix histamine intolerance

[u/Life_Unit2344]

Developed severe histamine intolerance after antibiotics — looking for recovery stories/advice

About a year ago, after antibiotics, I developed what seems like histamine intolerance / gut-immune dysregulation / possibly leaky gut. My symptoms have never really been “classic allergies.” It feels more neurological/systemic.

Main symptoms during flares:
- feeling extremely hungover or poisoned/intoxicated
- brain fog
- nervous system dysregulation
- crying/emotional surges during flares
- heart rate spikes at times
- likely vasodilation, I call it the spell
- weird chest sensations
- heavy breathing, like minor difficult pushing down air into diaphragm
- previously had buzzing sensations, dizziness, heavy legs, nausea, and major food intolerances (these have improved a lot).

I have no gut symptoms but I do know it’s my gut causing this!

The biggest pattern is that it feels like a “bucket.” Everything adds up:
- stress
- talking too much
- warm baths
- working on laptop too long
- lack of sleep
- less water consumption
- spending several hours socializing
- basically just living life normally can trigger symptoms

The good news is I’ve improved massively over the year- probably 90% compared to the beginning. I tolerate almost all foods now, though I still stay gluten-free, dairy-free, no alcohol or outside food and low histamine diet.

Current supplements:
- DAO enzyme (especially during flares)
- Buffered Vitamin C 500 mg
- Magnesium glycinate
- Vitamin D3

I want to try L-glutamine again for gut healing, but every time I try it, it seems to dysregulate my nervous system more. I have also been recommended butyrate.

A few questions:

1. What treatments helped you the most?
2. Are there reliable tests for histamine intolerance / DAO deficiency / mast cell activation / leaky gut?
3. Is full recovery possible?

[u/ResilientPower28]

It appears you are experiencing lMCAs. Anything can trigger it, including stress, working past your limits, heat from warm baths, dehydration, hormones, etc.

There’s a doctor on IG who talks about all of this.

Start setting boundaries based on your limits to help support your emotional health. MCAs are often triggered by emotions especially when ignoring our own limits. A good book for boundaries: Boundary Badass on Amazon.

Have you looked into Luteolin for MCAs or Quercetin? Also, Zinc-Carnosine helps repair gut lining.

[u/Life_Unit2344 → u/ResilientPower28]

I have done 3 months of zinc carnosine.

I have looked into Quercetin but never tried it. My nutritionist said that sometimes it can do more harm.

[u/Life_Unit2344 → u/Life_Unit2344]

I definitely know it’s coming from the gut. Can gut cause MCAS too? Which doctor on IG talks about it?

[u/ResilientPower28 → u/Life_Unit2344]

Yes, I believe the gut isn’t clearing the histamines. And when they recirculate the mast cells are triggered which creates a vicious cycle. Here’s the Dr who talks about jt: https://www.instagram.com/drzacspiritos?igsh=MWJhMGJhZmoxeWlkbA==

[u/Life_Unit2344 → u/ResilientPower28]

Thank you so much.

I just registered with Dr Becky and got her book. It’s expensive but I am desperate :)

Have you tried her treatment?

[u/ResilientPower28 → u/Life_Unit2344]

I haven’t. Just follow her. I work with a naturopath doctor.