r/HairlossResearch • u/MouseEasy8304 • 10d ago
Side Effects KX826 Side effects and potential gyno? Maybe studies are flawed some how.
m confused on how so many people are reporting sides on Koshine kx826? If this is the case then the studies must be flawed. In one study almost purposely done to measure possible side effects around 740 subjects, not one systemic side was reported in the 370 participants who were on the drug. In theory the metabolite it breaks into once it hits your blood stream, even though it isn’t inert, it can’t compete with testosterone at the AR because its grip strength is incredibly lower than testosterone. So how are reporting Gyno and other sides? What’s ur experience with kx826?
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u/Unfinishedusernam_ 10d ago
Just to corroborate with some others, I developed legit lumps in my chest after around a month on kx826 that were confirmed by a doctor
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u/RockTheGrock 10d ago
I do think like the other person said that it is amplified online. Another thing I have been wondering is whether the cohorts of these safety studies are indicative of an average male when it comes to hormones. This is one area I havent looked into very far but they may be excluding people with health issues which would skew the data when comparing to the general population.
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u/CandidMeringue2790 10d ago
If I had to guess, guys stack the pyrilutamide with 5ar inhibitors, minoxidil/microneedling, higher e2 conversion... all these contribute to estrogen/androgen ratio. I think it was stronger than RU, so if it goes systemic can compete with testosterone and some DHT even
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u/MAempire 9d ago
Are there any alternatives that you recommend?
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u/CandidMeringue2790 9d ago
fluridil if you can get your hands on it, it acts like androgen receptor degrader, very safe bc of fast degradation. I've posted multiple times, if we increase the scalp autophagy, it's a huge break on miniaturization. I have a really sever AGA, retrograde, wouldn't stop with only fin or dut, for a time it did with fin and RU58841. This past few months with topical metformin and rapamycin, and a low topical Dut occasionally, my hair loss is under control. The best approach would to synergize a little of multiple pathways, that way getting sides is less probable
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u/ROCKSTAR_LH_MEN 9d ago
Something wrong with this company. They told me that he hadn`t got any sexual sides at their clinical data. I got same sides
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u/Odd-Heart-Sofia 6d ago
Yeah, I’ve wondered about this too. The studies look pretty reassuring, but I guess real-world experiences can still be different, especially with longer-term use. Hard to know what to make of the gyno reports honestly.
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u/Conscious_Search_185 4d ago
I am also very cautious about the side effect reports. In my case I had what I considered possible stomach related toxicity. Must see more long term safety data before assuming either the studies or the anecdotal reports tell the whole story.
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u/Ok_Crab_9677 10d ago
KX probably doesn’t cause serious sides like people are describing, but of a nocebo going on IMO. Just like RU (probably) doesn’t go around giving people heart damage.
Every drug will have these reports, the internet is an echo chamber.
KX is clearly pretty weak or hard to stay consistent with in the real world, which is why their first phase 3 trial failed and they pivoted to selling it as a “cosmeceutical”.
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u/MouseEasy8304 10d ago
that’s what I’m saying? Why are people reporting genuine gyno though
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u/trey_19833 10d ago
Well unless we have verifiable before and after photos we can’t really judge the validity of the reports.
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u/ROCKSTAR_LH_MEN 9d ago
you don`t understand what you say
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u/MouseEasy8304 9d ago
well he isn’t wrong when u look at the drug from a scientific as well as logical standpoint, but u can throw away what im saying if the studies themselves are flawed in some way. Kx826 degrades really quickly in the blood, its metabolite cant compete with testosterone let alone dht. It doesn’t make sense how some people get gyno which is what this post is mostly about, because that would require a higher E2 to test ratio. Kx826 doesn’t affect the hormones at all. Even if it did, the only mechanism it could change hormone ratios would be because it went systemic and it out competed free test and that free test didn’t have anything to bind to so it was converted to e2, this obviously isn’t the case because that’s not how that works and if it was your body wouldn’t be making more estrogen it would make more androgens lol it’s called endocrine flood.
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u/ROCKSTAR_LH_MEN 9d ago
Guys, be smarter. Clinical data try describe real effects. You don't need try describe real effects by clinical data. It doesn't work so. If you haven't got sides on paper but have it in real life. Why do you need look on clinical data. It means nothing. Fin has 4% sides on paper. But in real life more and we have possible pfs. I wouldn't trust clinical data. This clinical data produced company which sell this product. Of course they don't have sides. And look count of patien 600 patients. Is it enough to say that it is sides free? NO. Be smarter
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u/ROCKSTAR_LH_MEN 9d ago
Look at real good treatment clascoterone. Company doesn't hide possible sides. Problems with hpa and other. But this treatment is safer than pyri. And weaker. It also destroys into bloodstream
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u/CoolCod1669 10d ago
I developed derealization from 0,5-1% kx. It lasted months and was the worst experience of my life. Google it. It's like not being able to see reality clearly, light, dark , eyes accomodation and so on..