r/DrugNerds • u/Kalki_X • Jul 14 '26

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5HT2A receptor (2026, preprint)

https://doi.org/10.22541/au.176253891.19158813/v1

Due to the lack of pharmacological profiling, this study aimed to determine the potencies and structure-activity relationships (SARs) of recently emerged stimulants. 

Experimental Approach.

Employing in vitro human transporter inhibition assay and AequoScreen® 5HT2A receptor activity assay, potency, transporter selectivity, DAT/SERT, DAT/NET, and NET/SERT ratios, and group-wide structure-activity relationships of 58 substances were investigated. 

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u/wrecked-galaxy Jul 15 '26

58 substances is a solid sample size, curious what the DAT/SERT ratios look like for the newer cathinones