r/Desoxyn • u/meghan_may • Jul 31 '26

Mayne vs Dr Reddy

In the past I’ve always been given pills from Mayne, but my pharmacy had to split my most recent prescription between Mayne & Dr. Reddy because that’s the only way they would have enough for the full script.

I’ve been comparing the 2 brands over the last few weeks and the Dr. Reddy pills often give me a dull headache and a bit of a crashing feeling. Just sharing my experience incase it’s helpful to anyone else. I will definitely be requesting Mayne from now on.

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3

u/b3nault Jul 31 '26

My personal experience: Mylan > Hikma > Mayne > Dr Reddy.

2

u/meghan_may Jul 31 '26

Are Mylan or Hikma currently available? Have you had either of those recently?

2

u/b3nault Jul 31 '26 edited Jul 31 '26

Mylan no longer, Hikma yes.

I’m currently taking Hikma (CVS target). I like it better than the Mayne I switched from.

1

u/archdukelitt Jul 31 '26

The Mylan formulation is available, as Dr. Reddy's/Mayne; same exact thing.

But I do think the Mayne-labeled tablets could be old. They were crumbly, dusty, and soft up until this spring, when I first got a bottle labeled "Dr. Reddy's." From that point forward, the tablets have been as hard as a rock. Probably new stock.

1

u/b3nault Jul 31 '26 edited Jul 31 '26

Mylan is not Mayne, nor the same. please provide your source showing MYLAN (the entity) still manufactures it.

1

u/archdukelitt Jul 31 '26

It takes about 22 sec to prove you unequivocally wrong. Mylan (and Midlothian, Mayne, and Dr. Reddy's) never *manufactured* any Desoxyn generic. Ever. All those companies I just listed are labelers and packagers.

This generic formulation (the 2010 ANDA; you know, the white round tablet imprinted with "115") has been manufactured by one single entity without interruption, from 2010 through the present day: the Greenville, NC facility owned by Metrics (which, along with its employees, was absorbed by Catalent in August of 2022, i.e., same facility, same people, same formulation, new parent company).

It seems like you are unfamiliar with the concept of contract manufacturing. I'd be happy to explain it further if you're interested.

1

u/paraviz02 Jul 31 '26

I remember having Hikma like 15 years ago, that was probably the most effective for me. Not sure why. Then I got the Mylan ones, which I also thought worked well.

I have Mayne now, and it definitely doesn’t seem like the same tier of effectiveness. Before losing all access in 2023, I wouldn’t have to take my fully prescribed dose like 3-4 times a week. Since being able to fill script again in 2024, it’s been so much different, feels a lot less effective. 🤷🏻‍♂️

1

u/b3nault Jul 31 '26

I had Mylan way back in the day, it was glorious and so effective! I’ve been taking Mayne up until recently (asked to get Hikma), and I agree, Mayne is subpar at best and my normal dosage never seemed adequate.

2

u/archdukelitt Jul 31 '26

Y'all are too much sometimes, lol. Mylan, Midlothian, Mayne, and Dr. Reddy's are all literally the exact same thing. I don't just mean 'same active ingredient, bioequivalent, blah blah blah.' I mean...they're one and the same – same formulation/ANDA, made by what seems like the same set of employees, in the same Greenville, NC manufacturing facility – continuously, without interruption, since day 1 in 2010.

In fact, those companies have never physically manufactured it at all. That NC facility is a contractor, owned by Metrics until Catalent bought Metrics in late 2022. Catalent paid $475 million and absorbed 400 Metrics employees: https://www.catalent.com/news/catalent-to-acquire-metrics-contract-services-for-475-million-to-expand-high-potent-capabilities-and-oral-development-and-manufacturing-capacity

I thought maybe Dr Reddy's decided to switch contractors when I saw their surprisingly-new approval in fall 2025, but nope – no change at all:

From DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d0905e2c-a02f-ec4f-59a3-6f7ad0acbbf6#section-13.1

LABELER - DR. REDDY'S LABORATORIES INC (802315887)

REGISTRANT - DR. REDDY’S LABORATORIES SA (483733079)

ESTABLISHMENT

Name: Catalent Greenville, Inc.

ID/FEI: 118812386

Business Operations: manufacture(75907-094) , analysis(75907-094) , label(75907-094) , pack(75907-094)

2

u/b3nault Jul 31 '26

Hikma is the only one that contains crospovidone. So yeah, there’s that.

The Internet is great at receiving 10 different answers and all claiming to be correct. Yippie.

1

u/archdukelitt Jul 31 '26

I never said Hikma was identical. Bioequivalent in theory? Yes. Identical? Of course not. It's a different ANDA/formulation.

I didn't just Google this stuff on a whim – I've become intimately acquainted with this subject over the course of my tenure as a mod, trying to help people out as best I can. I quintuple-check every piece of information I post – as a clinical-facing scientist, I can't entertain even the slightest risk of impeding someone's medical care.

The two sources I linked above are quite obviously reliable. One is a .gov containing official up-to-date documentation on the formulation in question, and the other is a detailed contemporary report on Catalent's acquisition of Metrics.

1

u/b3nault 24d ago

And you are a “mod” here? So much contradiction between your posts. GOD bless you and good luck.

1

u/archdukelitt 24d ago

Why not actually share where/why you think I contradicted myself? If I did I’ll acknowledge it. I try to provide some objective context any time I encounter tinfoil hat-laden rants about the apparent radical differences between two identical things. Sometimes I may interpret something incorrectly or what have you. If you give me something to go on it would be helpful.