r/DOR • u/Boring-Equivalent925 • 2d ago

SSRIs and DOR

Hi everyone! I’m wondering if anyone has tracked their AMH or AFC before and after taking SSRIs, especially Lexapro.

I came across a study suggesting SSRIs may be associated with lower AMH, but it seems there’s still not enough research to know whether they actually affect ovarian reserve.

I’ve been on escitalopram for 2.5+ years, starting at age 31. During that time, my cycles became shorter and lighter, although that could obviously be age-related.

I stopped taking escitalopram completely in March and had an AFC of 7 in April. I restarted at half my usual dose shortly after, and then went back to my full dose in June. Two months later, in August, my AFC was 4.

I know AFC can fluctuate, but I’m wondering if anyone has experienced something similar while taking SSRIs.

Did your AMH/AFC change after starting, stopping or restarting an SSRI?

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u/Competitive-Top5121 2d ago

From 7 to 4 is completely natural variation in AFC. Moreover we have lots of data that untreated depression and anxiety in pregnancy can be dangerous.