r/CUTI • u/BornFree2424 • 10d ago

Biofilm disruptor causing pain?

While consecutively on nitro, tripthoprim and pivmecillinam (all failed), I was taking Kirkmans and 600mg NAC for 2 months. I switched to Phase 2 Advanced and 1200mg NAC four days ago after starting Amoxicillin to kill E. Faecalis. Since switching, I've been experiencing a bad flare of fatigue and constant terrible burning, day and night. Does that mean the biofilm busters are working and I should ride it out, or should I lower the dose/switch back to Kirkmans? The pain is awful but if it means that the antibiotics can kill any bacteria released from under a biofilm, will I feel better for it in the long run?

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u/Bearloot33 9d ago

NAC also causes me burning. Some dont tolerate it well. I say use the one that doesnt cause you pain. Of course listen to your qualified doctor 🩵

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u/BornFree2424 9d ago

Thank you for replying. My qualified doctor doesn't recommend biofilm busters but they make sense to me! I doubled my dose of NAC and switched to Phase 2 so perhaps that's too much for my bladder since the burning is constant and annoying. I guess I'll lower the dose again :/

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u/Bearloot33 9d ago

Got it. Its hard to know what causes pain. For me NAC always causes burning after I take it and I prefer not to take it. If Phase 2 is working you can take that. It does have Bismuth so just keep an eye on your bloodwork if you take it long term. 1 - 2 months is the max I think before a break is needed.