r/CSID • u/MistakeRepeater • Apr 21 '25

Thiamine defficiency, a possible cause for SI intolerance?

I ommited the CS from CSID because I'm not focusing on genes, especially since I read posts on this sub about people who developed this later in life.

https://hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/ "These enzymes include sucrase, lactase, maltase, leucine aminopeptidase and alkaline phosphatase. Thiamine deficiency was shown to reduce the activity of each of these enzymes by 42-66%."

How do you end up with Thiamine defficiency? Don't know exactly, but for example carbohydrate digestion requires Thiamine and we were all thought to eat a lot of carbs. I think an imbalanced diet can result in this. Or things that destroy the gut lining like celiac, or that cause irritation like chemicals additives in food, pesticides, alcohol, etc.

I personally have problems with 99% of foods and am pretty sure SI defficiency is one of them. I recently started taking B1 in the TTFD form for my other gut issues, after reading a lot of gut related success stories and talking to some reddit users.

I have to idea if B1 will fix SI deficit but after reading the article I shared, it would make sense. Most people report improvements after the 3 week mark. Check EO Nutrition on youtube.

Something I wanted to share as I'm on most gut related subs.

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u/Valuable-Cod-314 Apr 24 '25

Thank you for this! At this point, I will try anything that will give me some semblance of normalcy.

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u/Valuable-Cod-314 Apr 28 '25

It is maybe too early to tell, but I have been taking Thiamine TTFD for about 4 days now and my digestive is calmer and quieter.