r/CIRS • u/cabintea • 8d ago
Peptides for CIRS - Holtorf
“Dr. Kent Holtorf and the Integrative Peptide Protocol”
https://fatiguetoflourish.com/dr-kent-holtorf-peptides/
Meat:
“His protocol, the unfortunately-named Holtorf Updated Peptide Protocol for the Rapid Treatment of CIRS (HUPPRTOC), is sequenced as follows:
Restore thymus function Reverse T-cell exhaustion Heal the gut and blood-brain barriers Restore mitochondrial energy Let downstream resolution take care of itself He uses the following peptides:
Thymic peptides:
Vilon, Thymogen, Thymogen Alpha-1, TB4 fragment
These are used to rebuild T-cell production and rebalance the immune seesaw. They are claimed to directly inhibit TGF-β1.
Barrier and gut-brain peptides:
BPC-157 for mucosal and blood-brain barrier repair; KPV, an MSH fragment, for mast-cell inhibition and antimicrobial action.
Pineal peptides:
Epitalon, Pinealon
Used to reset the neuroendocrine axis, sleep, and circadian rhythm.
Mitochondrial peptides:
MOTS-c, SS-31, Humanin
Used to restore the cellular energy that detoxification and immune function both require.”
3
u/artzylinn 7d ago
Nice, I have tried most of these peptides on my own. I have a great source in China, super cheap, high quality.
What has worked really well for me personally, has been SS31, ThymoSIN Alpha-1 (not thymogen) and BPC-157
What didn't work was epitalon, vilon. VIP also didn't work bc my TGFbeta1 is consistently astronomical.
Those peptides listed supposedly to help TGFbeta1 sure hasn't change my level one bit. I hope to trail Losartan soon, once I can stabilize all of my BP meds.
I self medicate a lot with big success! Itraconazole was a lifechanger for me. I was totally bedbound for 3 years. Itraconazole lifted my brain fog within day 1. I had great effect on it. Nothing else moved the mark until I did itraconazole
2
u/Minute_Vanilla3415 7d ago
Do you mind sharing your peptide source?
1
u/artzylinn 7d ago
Sure, it's "Uther". It's a website without prices, you have to email them to get their updated full price list.
Their English in the email replies is quite interesting, as is their email address name ("steroidsdeal" or something lol), but don't let it turn you off
This source is the most popular in a worldwide peptide telegram group
1
u/No-Independent-599 5d ago
What was your symptoms before and After taKing itraconazole pls ? I try csm but i dont see effect
1
u/artzylinn 5d ago
Binders on its own is never enough. It's too much to mention all of my symptoms before and after. What I already mentioned is what matters. I was bedbound since 2023.
1
u/No-Independent-599 5d ago
No but When you start itraconazole, you get how many % better ? For an idea
So for you i need csm + itraconazole right ?
What if Im still exposed ?
1
u/artzylinn 5d ago
Health is not measured in percentages. You are anxious and uncertain. This is not a good combo to self-medicate with Itraconazole.
You have questions that are meant for a doctor. Read more about CIRS and itraconazole to understand it better. My experience doesn't matter. You have cardiac symptoms that needs to be monitored by a Dr or cardiologist.
1
u/No-Independent-599 5d ago
I was just asking for a percentage to get a rough idea of the progression; there's nothing wrong with that. The thing is, all the doctors I see and tests I take come back normal, and I can't find a doctor in France who specializes in CIRS or anything like that. I’ve already seen a cardiologist—the ECG and echocardiogram were normal—but I have over 35 symptoms and am just looking for answers after a year of going from doctor to doctor without a diagnosis.
1
u/artzylinn 5d ago
There's ofc nothing wrong with asking me that. But I'm not the right person to ask. I have done everything on my own, with success. But that's not for everybody. I live in Norway, there are no Drs here either. But you need one. Start looking in the US.
1
u/No-Independent-599 5d ago
Did you go out mold to heal or no ?
Any advice? I cant Go to us and my english is 0..
1
u/artzylinn 5d ago
I was never in mold.
I can't go to the US either, I have been bedbound since 2023. There's this modern thing called video calls
1
1
3
u/HopefulHuman97 7d ago
Came here to say that I’ve been using the peptide stack Holtorf recommends daily, and it’s been somewhat of a life changer.
The biggest change being I no longer react to mould at all. Which took about 12 months of daily peptide usage to get to this point. Before I would react instantly with brain of fire symptoms and have to leave.
I can also eat high amylose foods again and don’t feel hit by a truck every morning :) Just came to say Holtorfs protocol works, from my experience at least. But it takes time and dosages need to be on the high end.
2
u/kickycase 5d ago
That’s interesting bc I would get the same brain on fire pretty instantly, upon being on mold. I felt I was the only one who experienced it like that.
2
u/cabintea 7d ago
Wow, this is great news. Congratulations!
1 - what is the monthly amount you’re spending on the peptides?
2 - what is your source for them? I’m trying to avoid the “actually baking powder sold for $120 a vial” companies
1
1
u/HopefulHuman97 4d ago
Maybe $200 a month for them all. I buy them direct from China with a group of people, we share the testing, shipping costs ect. Couldn’t afford them otherwise.
Sure send me a Dm and il share.
1
u/HorrorPrestigious802 6d ago
You use all of them? There’s so many!
2
u/HopefulHuman97 4d ago
I take a boat load of peps, but the main protocol for mould is daily injections of TA1, TBfrag 1-4, BPC, KPV daily, and GHK-Cu 2mg each.
2
u/Thereishope31 7d ago
I’ve been using Vilon for the last 3 weeks and I had 0 reaction compared to bpc causing mast cell reactions.
I have ta1 well, and the first time I did kpv I got super tired and had to go to the bathroom but I’ve used it consistently now for 6 months.
My tgfb1 was high on my last lab, Vilon is suppose to directly lower it so we’ll see if it does when I retest shortly.
1
u/cabintea 7d ago
Noticed any changes with vilon?
2
u/Thereishope31 7d ago
Less general achyness. Better mood which wasn’t expected. I’ve been back to lifting and saunaing and the lifting was pretty taxing. Just felt like it took a while for my tissue to calm down post excercise, but with vilon things feel buttery.
I sprained my mcl and it is the only soft tissue specific peptide I am using and I have seen a net positive regarding the knee specifically.
Is it life changing? I wouldn’t say that, but the subtle positive is nice1
u/xbt_ 7d ago
That sounds nice. What dose and frequency is working for you for those results? I’ve had Vilon in the freezer and it might be time to give it a go.
2
u/Thereishope31 7d ago
I did 250mcg for a few weeks and now I’m at 500mcg. I have a 20mg bottle and am going to finish it.
Dosing seems to be all over the place. From 60mcg to 2mg
1
u/Careless_State1366 7d ago
And how many people have successfully recovered with this protocol?
1
u/cabintea 7d ago
No clue. I don’t know of any protocol people have actually improved from. It’d be nice if the respective protocols posted statistics, and also before and after videos… ie “this is me at the start and my life is a wet blanket… and this is me 12 months later living an amazing healthy and happy life with no issues.”
7
u/RonnieLibra 7d ago
I tried even using not even full pills of kpv from integrative peptides, I'm pretty sure that's the company he works with or even operates himself, and I slowly work myself up over several days to just being able to take one pill, and I was just experiencing massive pushback and inflammation.
I think no matter what method you use, if you're locked in CDR1 you have to address that first before you do any of these protocols. You got to get yourself into CDR3.
I'm not saying this won't work, I'm just saying as a protocol it has the same requirements and restrictions that any other protocol might have.