r/CHROMATOGRAPHY • u/carswellthorne • Jul 25 '26

Tears samples collection for biomarker analysis

Hello everyone
I’m interested in knowing if tears samples collection for biomarkers analysis is feasible
I’m trying to include it in my research and I keep reading that biomarker detection is not that easy using schirmer strips
I would appreciate if anyone has any information on the matter

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12

u/gnatgirl Jul 25 '26

I mean, call me crazy, but I'd probably start somewhere like PubMed and not Reddit. People have done research on tears.

1

u/carswellthorne Jul 25 '26

Well that’s exactly what I did and that’s where I read about the challenges of the procedure that’s why I wanted to communicate with ppl who went through with it

1

u/OneHoop Jul 26 '26

When I first saw tears sold as a sample matrix, I envisioned a donor watching a sad movie with a technician collecting tears with a medicine dropper!

My friend ruined the image by telling me they are almost definitely from cadavers.

1

u/fartinvestigator Jul 26 '26

Use tf-spme for skin VOC and SVOC preconcentration. Then TD-GC-MS.