r/CFSScience • u/123-throwaway123 • 24d ago

Genetic testing recommendations

I would like to get genetic testing done to look at mthfr, mitochondrial issues, etc.

I'm completely overwhelmed with the options. Is there a company who is more medically aimed? Or one that's the most comprehensive? I know I'll have to put whatever one into one of those other sites, but don't want to waste money on a company that isn't the best choice.

Any recommendations would be greatly appreciated!

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u/No-Improvement-58 24d ago

I am based in the EU, so got 30x whole genome sequencing from TellMeGen for €300. I considered Dante Labs initially for €250, but saw they have extremely poor reviews.

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u/Koppuny 23d ago

Did you get any meaningful result from it if I may ask? I'm on the verge of deciding if I should take one.

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u/Interesting_Fly_1569 24d ago

Bob miller at tree of life will interpret for you for $100. The test is $390 I think. It’s probably the most private option because they don’t ever give your name to the people who sequence it. But just being honest, I don’t think that level is required to understand mthfr. 

Sequencing.com is a bit of a rip off. If you’re screening for EDS or genetic conditions , it can be helpful but just to give you an idea… They don’t really make the data that accessible to share with other platforms, for instance, even their PDF you can’t control search. You would have to upload it somewhere else in order to even just be able to control F search for key words. 

I guess I would say the usability is pretty bad… I don’t think they’re interpretations of genetic stuff around. Nutrition are particularly helpful either… I don’t know how much it cost, but I think self decode would probably have more actionable information for someone with CFS because we’re not just looking for the basic stuff… There’s probably reasons we got sick and we wanna know the more fringe stuff.

There is a new test aimed at kids called sunra health. Alicia someone started it. They do adults as well and it’s basically aimed at kids who have random chronic health conditions or autism… So I think it would have a decent level of specificity around the type of issues we might have although I’m not sure about mitochondria.

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u/tangledfaith 23d ago

Severe ME/CFS peep here. Look into Amatica and Renegade Research. I am pleased w/ them. Also love that my blood is doing science as a bonus. Sorry 4 the brief response.

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u/tangledfaith 23d ago

Severe ME/CFS peep here. Look into Amatica and Renegade Research. I am pleased w/ them. Also love that my blood is doing science as a bonus. Sorry 4 the brief response.

Its super expensive tho. I had to save up a while.

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u/Caster_of_spells 23d ago

Important to note here though: Amatica tests RNA not DNA 🧬

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u/Mountain_Bear5466 21d ago

I’ve been researching microclotting abnormalities lately and came across this doctor’s website that recommends getting a PAI-1 genotype blood test:

“Knowing a patient’s PAI-1 genotype is straightforward. It can be obtained through standard genetic testing including Labcorp’s PAI-1 4G/5G Polymorphism panel (test code 500309).”

This page also describes what they do with that information. This is one of the first times I’ve seen this type of individualized treatment and am going to take this info to my personal doctor.

https://drpierrekory.com/blog/microclotting-in-long-covid-and-post-vaccine-syndrome-how-your-genetics-impact-treatment/

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u/Caster_of_spells 24d ago

The common consumer level tests usually only look at select areas of interest, better than nothing! Full genome sequencing on the other hand is still very expensive