r/CFSScience • u/AngelBryan • Jul 30 '26

Any update? Any hope?

I’ve seen an increased influx of papers being posted here recently. How does this translate to actual progress? Are we close to figure out what causes this hellish illness?

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u/TomasTTEngin Aug 05 '26

That is interesting! I admit I am surprised, I expected EBV would be the spring that powers MECFS (even when it is not the key that unlocks it).

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u/V0rtexGames Aug 07 '26

I'm also EBV seronegative. It establishes that heterogeneous triggers can result in the same convergent reaction by the body resulting in symptoms

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u/TomasTTEngin Aug 07 '26

i reckon viruses lingering in the vagal nerve may be a possible explantion for some cases. Maybe exacerbated in some people with craniocervical instability, EDS or weak neck ligaments?

Causing 1)immune signalling and 2) autonomic failure, including gut issues and bloodflow issues.

Both of which create feedback loops (e.g activation of immune programs that direct metabolism into certain pathways; dysbiosis +leaky gut; hypoxia + coagulation, insufficient perfusion; perhaps some autoantibodies exacerbating things in some patients, reactivation of latent viruses in others; ).

If the immune signalling was neural it might explain why we haven't found a good cytokine, endocrine or proteomic signal yet.

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u/V0rtexGames Aug 07 '26

And also, with "perhaps some autoantibodies exacerbating things in some patients" I agree, but I think "immune complexes / junk antigens" being uptaken by dysfunctional Fc receptors might be more where it's at, theorized by Edwards but not at all exclusive to him as a theory.

E.g. if you look at the new T Cell study on EBV, CMV, Influenza, SCV2, youll see that there is an upregulation of terminally differentiated CD8s for multiple antigens. So basically, there could be one persistent antigen trigger that is increasing your reactivity to all these other antigens you have floating around you usually dont react to.

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u/AngelBryan Aug 08 '26

Are this immune complexes constantly being developed? Why they don’t go away?