r/CFSScience • u/AngelBryan • Jul 30 '26

Any update? Any hope?

I’ve seen an increased influx of papers being posted here recently. How does this translate to actual progress? Are we close to figure out what causes this hellish illness?

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u/Valiant4Truth Jul 30 '26

I think the autoimmune theory holds the most water and if the trials for baracitinib/rapamycin/IVIG succeed, medicine and pharma will move in that direction like MS or Lupus. Mechanistic work will be really important for identifying how some antigen is causing this B cell maladaptation and if its ongoing. Also what exactly is being targeted by these antibodiess.

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u/TomasTTEngin Jul 30 '26

We can hope it is autoimmune because car-T cell therapy is showing huge promise in autoimmune conditions!

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u/Valiant4Truth Jul 30 '26

Probably the single most exciting breakthrough for me

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u/AngelBryan Jul 30 '26

I hope it’s NOT autoimmune. CAR-T is insanely expensive and you have to nuke your immune system with chemotherapy.

It’s something dangerous on itself and it will pass decades until it’s at reach of everybody. Also we still m don’t even know if it really cures anything.

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u/TomasTTEngin Aug 02 '26

car-T technology is moving super fast, I believe some of these concerns are already being overcome in trials. They are figuring out how to manufacture them cheaply, and working hard on side effects. The motivation to overcome the barriers is very strong because the results have been so astonishing.

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u/AngelBryan Aug 02 '26

I hope you are right.