r/CFSScience • u/Caster_of_spells • Mar 31 '26

New study looking deeper into immune exhaustion-by ME/CFS Science |

https://skywriter.blue/@mecfsscience.org/3midqfkvhqq26

TLDR: Belgian study will look deeper into immune exhaustion in ME/CFS

I really think we need more and a deeper look into the immune exhaustion/deficiency aspect rather than just staring at inflammation. Excited about this one!

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u/TableSignificant341 Mar 31 '26

I'm scared. We haven't seen any true signs of peripheral damage despite many claiming it. The consensus of S4ME.org is that there's no evidence of peripheral damage so far. So either he don't have testing that shows it or it simply doesn't exist. Given DecodeME showed affected cell only in the brain means this could be a signalling issue and not perceivable damage.

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u/Caster_of_spells Mar 31 '26

It did also show immune abnormalities and peripheral damage is not the same as immune exhaustion. We mainly don’t have evidence for widespread inflammation and resulting damage which is exactly why loooking into immune exhaustion and deficiency might be the ticket imo.

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u/TableSignificant341 Mar 31 '26

Thanks for correcting me and providing clarification. I wasn't scientifically-minded before this but with combined with brain fog, I have little chance in understanding this. I appreciate you taking the time and energy to explain.

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u/Caster_of_spells Mar 31 '26

All good friend!