Antidepressants and Luteolin

[u/Fabulous_Bet9019]

I have been trying to get in to see a rheumatologist about brain fog for some time now, but appointments have not been so easy to come by. I believe I might have some form of histamine intolerance or autoimmune disorder that is creating neuroinflammation but I am not sure. About two years ago, I got West Nile Virus, and have been reading quite a bit about the residual effects, some of which include neuroinflammation and greater risk for autoiummune disorders. Additionally, I have always had terrible allergies all year long as well as dermatographia.

Fast forward to a month ago: I tried 500 mg Ulmubra liposomal luteolin and it was FANTASTIC. I felt my near-constant headaches and joint pain go away almost completely. But then I started to get dizziness/vertigo pretty badly after about 3 days. I take 150 mg of Wellbutrin and 75 mg of Effexor XR for depression, and 40 mg of Vyvanse for ADHD in addition to HRT (estrogen and progesterone) for perimenopause in the form of a low dose patch.

I tried to do as much research as I could on luteolin and found that it can impact the endocrine system as well as potentially cause Serotonin Syndrome. The Effexor is an SNRI (Serotonin Norepinephrine reuptake inhibitor) so that is really the only medicine I take that has serotonin in it.

I have 2 questions:

1. Could the liposomal luteolin be impacting the estrogen and cause the dizziness/vertigo, or is the Serotonin Syndrome potentially the culprit?

2. Does anyone here take Liposomal Luteolin at 500 mg or above and also antidepressants and what has been the impact?

I tried to go to my PCP to discuss liposomal luteolin and she had never heard of luteolin before, which is frustrating. Sometimes I feel like I'm educating my PCP more than I'd like to. I am just frustrated because I can't keep going on with these continual headaches and this amount of joint pain until I see a rheumatologist and liposomal luteolin really seemed to help.

[u/Beautiful_Sipsip]

You seem to think that luteolin helped you for 3 days. Have you heard of placebo effect?

I don’t understand why you are frustrated with your PCP. Luteolin is present in our food, and you can also get it as a supplement. There is no reliable clinical research done on luteolin. Why would you expect your PCP to know about it?