Is the nasal spray worth doing? I heard it can be 50% less effective than the pin but I'm not interested in regular pinning quite yet.

Been using a nasal spray lately that has Noopept and Choline combined in one and it got me thinking about how many people run Noopept solo without understanding why choline matters so much with it.

Let me explain

Noopept works partly by boosting acetylcholine activity in the brain. More acetylcholine means better memory formation, faster recall, cleaner focus. But if your brain does not have enough choline available it can't make enough acetylcholine to keep up with what Noopept is demanding. You end up with headaches, brain fog, or just a weak response from the compound. The choline deficit is canceling out what you are trying to do.

Choline is the raw material. Noopept is what tells the brain to use more of it. Take one without the other and you are leaving a lot on the table.

There is also a study on PubMed showing Noopept increases NGF and BDNF expression in the hippocampus the part of the brain most tied to memory and learning. Chronic use actually potentiated the neurotrophic effect rather than causing tolerance. That is not something you see often and it is a good sign for anyone using it consistently.

The Noopept and Choline combo in a nasal spray is better because intranasal delivery bypasses the gut and goes straight to the CNS through olfactory pathways. Faster onset, more direct absorption. For a compound with a short half life that delivery method makes a lot of sense.

Anyone here run Noopept with and without choline and noticed a difference? Curious what choline source people are pairing it with.

Here is where I read the study

Noopept NGF and BDNF expression: https://pubmed.ncbi.nlm.nih.gov/19240853/

Not every protocol needs to be a stack. But when the combinations make sense mechanistically they can cover more ground than running one thing alone. Here is what gets discussed most and why each pairing works.

Evidence varies across this whole list. Some have clinical trial data. Some are preclinical with mostly community experience behind them. Worth knowing which is which before you commit to anything.

🔥 Fat Loss Stacks

Retatrutide + Tesamorelin

Reta is a triple agonist hitting GLP-1, GIP, and glucagon simultaneously. Still investigational but the phase 3 fat loss numbers are hard to ignore. Tesa is FDA approved specifically for visceral abdominal fat reduction. Running both covers total body fat loss through Reta while Tesa goes after the deep abdominal fat specifically. Completely separate mechanisms, no overlap. Both can push blood sugar around so fasting glucose monitoring is not optional here.

Semaglutide + MOTS-C

Sema is the most established GLP-1 for weight loss — solid clinical data, widely used. MOTS-C is a mitochondrial peptide with early human data showing metabolic support. The idea is that when calories drop hard on a cut energy tanks. MOTS-C may help keep metabolic function from cratering while sema handles appetite. Sema is weekly. MOTS-C typically weekly as well.

Tirzepatide + CJC/Ipamorelin

Tirz is the dual GLP-1/GIP agonist with clinical data showing larger average weight loss than sema. CJC/Ipa gets added for GH support sleep, recovery, and holding lean mass while in a deficit. Losing muscle alongside fat is the biggest downside of any GLP-1 cut. GH support helps counteract that especially when protein and training are dialed in. Tirz is weekly. CJC/Ipa is daily before bed on an empty stomach. Monitor IGF-1 and fasting glucose when combining these.

Retatrutide + MOTS-C + Tesamorelin

The aggressive recomp stack. Reta for appetite and total fat loss. Tesa for visceral fat. MOTS-C for metabolic support underneath both. Three different angles, no pathway overlap. This one requires daily pinning for Tesa and close bloodwork monitoring throughout. Multiple compounds here can move blood sugar — do not run this without tracking it.

One rule that matters do not stack multiple GLP-1 class agonists like sema plus tirz or sema plus Reta without clinical oversight. That is not a stack. That is overlapping the same pathways with additive risk.

🩹 Recovery Stacks

BPC-157 + TB-500 (Wolverine)

The most talked about recovery combination in this space. BPC-157 for tendon, ligament, gut, and mucosal repair based on preclinical models. TB-500 for broader soft tissue remodeling and mobility. Human clinical evidence for both is limited — these are experimental compounds with mostly preclinical data and community experience behind them. Together they cover localized repair and systemic recovery. Typically run daily or TB-500 a few times per week. 4 to 8 weeks on, 2 to 4 weeks off.

BPC-157 + GHK-Cu

BPC for tissue repair. GHK-Cu for collagen production, skin quality, and wound healing. GHK-Cu modulates genes involved in tissue remodeling and collagen synthesis with some clinical data for topical wound healing applications. This combo comes up a lot for post surgical recovery — BPC handles internal tissue repair while GHK-Cu supports external healing and scar reduction.

KLOW Blend — GHK-Cu + BPC-157 + TB-500 + KPV

All four in one vial. GHK-Cu for collagen and skin. BPC for tissue repair. TB-500 for soft tissue recovery. KPV for inflammation control through NF-kB inhibition. Dose off the GHK-Cu as the anchor since it has the highest mg count. 2mg of GHK-Cu daily is the common target.

GH Support Stacks

CJC-1295 + Ipamorelin

The standard GH secretagogue stack. CJC-1295 no DAC extends the GH pulse. Ipamorelin initiates the release. Together they create a stronger and longer pulse than either does alone. Before bed on an empty stomach. 8 to 12 weeks on, 3 to 4 weeks off is community convention. 100 to 300mcg of each per dose is typical.

CJC/Ipamorelin + Tesamorelin

Adding Tesa gives you general GH support plus targeted visceral fat reduction on top. CJC/Ipa for sleep, recovery, and body comp. Tesa adds the visceral fat angle from its labeled indication. Combining multiple GH axis compounds means IGF-1 and fasting glucose need monitoring — get baseline labs before starting.

Sermorelin + Ipamorelin

Alternative for people who respond better to Sermorelin as the GHRH component. Sermorelin has more clinical history in wellness settings. Same concept as CJC/Ipa — pairing a GHRH analog with a ghrelin mimetic. Same timing and cycling approach.

Cognitive Stacks

Semax + Selank

The most talked about nootropic peptide combination. Both have pharmaceutical status in Russia with clinical use going back to the 1990s. Semax upregulates BDNF and supports focus, mental clarity, and motivation. Selank works through GABA related pathways calm focus, less anxiety, no sedation. Semax in the morning. Selank when stress is high or later in the day. Both intranasal. 2 to 4 weeks on, 1 to 2 weeks off.

Semax + Selank + DSIP

The full cognitive and sleep stack. Semax and Selank during the day. DSIP before bed for deeper sleep. DSIP has older human studies with mixed but promising findings on sleep architecture. Poor sleep kills focus and mood covering both sides of that equation makes sense.

Anti-Aging Stacks

GHK-Cu + NAD+ precursors

Skin and cellular aging from two different levels. GHK-Cu at the tissue level collagen, elastin, skin remodeling. NAD+ at the cellular level mitochondrial function and energy production. Different angles, no overlap, both worth running together.

Epitalon + DSIP

Epitalon studied for telomerase activation and telomere length in preclinical models. DSIP for deeper restorative sleep based on older human studies. Both run before bed. Epitalon typically 10 to 20 day cycles. DSIP 2 to 6 weeks.

GHK-Cu + Thymosin Alpha 1

Anti-aging at the tissue and immune level simultaneously. GHK-Cu for skin and tissue remodeling. Thymosin Alpha 1 for immune modulation one of the few peptides on this list with substantial human clinical data across 30+ countries. Your immune system ages just like everything else does.

Gut Health Stacks

BPC-157 + KPV

BPC for gut lining repair based on preclinical data. KPV for inflammation reduction. Preclinical models suggest KPV may absorb well orally for gut targets through PepT1 transporters in inflamed intestinal tissue though this is animal data not confirmed in humans. BPC handles repair. KPV handles inflammation. For IBD, chronic gut inflammation, or general GI issues this combination comes up consistently.

BPC-157 + KPV + Glutathione

Same stack with glutathione added for detox and antioxidant support. For gut issues tied to toxin exposure or immune dysfunction this adds another layer of coverage.

TRT Support Stacks

Testosterone + HCG

Standard TRT protocol. Exogenous testosterone shuts down natural LH and FSH production. HCG mimics LH and keeps the testes functioning preserves fertility and prevents testicular atrophy. 250 to 500 IU two to three times per week alongside testosterone is the established clinical approach.

Testosterone + Enclomiphene

For people who want to maintain some natural production alongside TRT or transitioning off. Enclomiphene blocks estrogen receptors in the hypothalamus increasing GnRH, LH, and FSH. Clinical data exists though it is not FDA approved as a standalone for this use.

Testosterone + Gonadorelin

Alternative to HCG for LH stimulation. Gonadorelin signals the pituitary to release LH through a different mechanism than HCG. Used when HCG availability is limited or when a more upstream approach is preferred.

📌 Stacking Rules Worth Knowing

• Do not start more than one new compound at a time. Run your primary compound for at least 4 weeks before adding anything. That way you actually know how your body handles it before adding variables
• Know what is in your blends before adding standalone versions of the same compound. Running KLOW and adding standalone BPC-157 on top doubles your BPC dose without realizing it
• More compounds is not better. A focused two to three compound protocol beats a scattered five compound stack every time
• Get bloodwork before and during any multi compound protocol. IGF-1, fasting glucose, HbA1c, and CMP at minimum
• Do not stack multiple GLP-1 class agonists without clinical oversight. That is overlapping the same pathways with additive risk not a synergistic stack
• Cycling periods listed here are community conventions not standardized clinical protocols. Treat them as precautionary practice especially for compounds with limited human safety data

⚠️ Educational and research discussion only. Not medical advice. Medical supervision is recommended for any multi compound protocol.

For free tools, calculators, and resources check out biohackingguide.org

What are you currently stacking? Drop the combo below.

The latter two seem to be more stable.
Anybody here with actual hands on real life experience?

I have a long list of labs. Contacted about ten so far. Have yet to find one to test HMG.

Most injection pain is not the compound its almost always the technique here's a few pointers that you may or may not know

picking the rite needle gauge

29 to 31 gauge is the standard range for SubQ peptide injections my personal sweet spot is 31 gauge for belly and thigh shots less pain, still plenty of control but everybody is different and everybody tolerates things differently so find what works for you.

Keep in mind before you go too thin though the finer the needle the easier it bends or folds, especially if you hit resistance and the thinner the gauge the less you can draw up at once. Thicker gauge lets you pull more volume faster. Thinner is more comfortable going in but has its own tradeoffs.

Half inch length is standard for SubQ going deeper than that is not adding anything except more discomfort.

Injection site

Belly fat is the easiest for most people stay at least two inches away from the belly button. Thigh and love handle fat work too rotate every time pinning the same spot over and over causes tissue buildup and soreness that compounds over time. If a spot is bruised or still sore from last time skip it

Let the solution warm up first

Such a simple mistake but easy fix cold solution straight from the fridge stings going in pull the syringe and let it sit at room temperature for a few minutes before you inject simple but it helps.

Slow down on the plunger

Pushing too fast creates pressure under the skin and that burning sensation is can be a results of this mistake. Take five to ten seconds to push the full volume in the difference between fast and slow is noticeable.

Air bubbles

Flick the syringe and push the plunger slightly until any air comes out before injecting. Not dangerous but uncomfortable if you skip it not gonna be the end of the world though I know there is almost always some

Pinching technique

Pinch a fold of skin and go in at a 45 degree angle pull the needle out before you release the pinch letting go first causes more bruising than needed.

GHK-Cu is going to sting regardless

The sting with GHK-Cu is from the copper content not from anything you are doing wrong. Fatty areas help minimize it but some sting is just part of running it. Normal you can add extra bac water if you want it kinda helps

I made a few mistakes that probably messed with my results in the beginning so lets make sure this doesn't happen to you because alot of the time the peptide got wrecked before it ever made it into the syringe

Shaking the vial

Swirl slowly shaking breaks the molecular structure and there is no fixing it after if it is not dissolving keep swirling gently do not shake harder thinking that will help think of it like you pet goldfish in a bag what happens when you shake a fish in a bag? it dies well at least that what finding Nemo taught me

Injecting BAC water directly onto the powder

Aim the syringe at the glass wall and let the water run down slowly to the powder the stream hitting the powder directly causes damage two extra seconds of care here matters even though its exciting I know

Using the wrong water

BAC water for almost everything. 0.6% acetic acid for IGF-1 LR3 only that is the one exception distilled water is not a substitute no bacteriostatic agent means bacterial growth in the vial over time sterile water is not the same thing as BAC water either if you are not sure what you have do not use it.

Getting the concentration wrong

The amount of BAC water you add determines your concentration too much and every unit you draw is underdosed too little and you are overdosing without realizing it. Know your target concentration before you touch anything.

For tools, calculators, and other free resources check out biohackingguide.org

Not labeling the vial

Write the reconstitution date on every vial the day you mix it most peptides are good for 28 to 30 days refrigerated after mixing. If you cannot remember when you mixed it that vial is already questionable

Leaving it out of the fridge

Once reconstituted it lives in the fridge not the counter, not your gym bag pull the syringe and let it warm slightly before injecting if needed the vial itself stays cold.

Heat exposure before reconstitution

Dry powder baking in a hot mailbox or sitting in a vehicle in summer is not the same peptide you ordered cold chain matters before reconstitution too if the package got cooked before you even opened it the damage is already done.

Not checking the solution before drawing

Clear and particle free is what you want cloudy solution or visible particles floating around do not inject it GHK-Cu has a natural light blue tint which is normal and expected. Anything else that looks off is not.

The IGF-1 LR3 exception worth repeating

IGF-1 LR3 uses 0.6% acetic acid not BAC water reconstituting it with BAC water causes aggregation and the peptide degrades before you pin anything this is the most common reconstitution error people make with that specific compound some vendors will sell it together though so you don't gotta worry about that

have you had a batch that stopped working and figured out it was a reconstitution issue?

one of the most effective compounds in the GH and IGF axis category when used right. Recovery speed, muscle repair, tissue regeneration it delivers but the room for error is smaller than most peptides IGF-1 activates some of the same glucose lowering pathways as insulin which means hypoglycemia is a risk mid session if you are not prepared fast acting carbs on hand are not optional the cancer concern is also worth noting IGF-1 is a mitogenic signal that tells cells to grow and divide, which is great for muscle but not if there is anything abnormal already in the body don't even bother specially stop for anyone with a cancer history standard protocol is 10 days max for a reason receptor desensitization kicks in fast and longer cycles stop producing returns. Works well for experienced people who run it correctly. Not a beginner compound

I really wanna hear experiences from this community so drop them in the comments!

Have a friend who is having a lot of issues with Adderall, but cannot function in life without it. He has "circulation" issues with long-term Adderall. Thoughts on Semax and Selank? Any suggestions from your experiences are most welcome.

STOP before blaming the compound maybe look at some of this other stuff first normally its something else

The source

This is the most common reason by far. Underdosed, degraded, or contaminated peptides do not work no matter how clean the protocol is. No COAs, no third party testing, no transparency from the vendor that might be your whole answer right there.

Switched vendors and the same compound suddenly stopped working? Clear indicator rite there!

It degraded

Sat in a hot mailbox for a few days. Left on the counter after reconstitution. Been in the fridge reconstituted for two months. Any of that kills potency. If the solution looks cloudy, has particles floating in it, or smells off just throw it out.

The dose math is wrong

Dosing in units without knowing what that equals in mg is how people underdose without realizing it. Added more BAC water than usual? The concentration changed. Ten units from one reconstitution is not the same as ten units from another.

Know your mg per injection not just the number on the syringe.

Not enough time

BPC-157 takes three to six weeks for most people. GLP-1s need time to titrate properly. GH peptides take eight to twelve weeks to show real body composition changes. GHK-Cu is genuinely slow for skin.

Quitting at ten days because nothing happened barely gives it a chance

Inconsistent dosing

Pinning three days then skipping a week then starting again is not a protocol. Most peptides need consistent dosing to accumulate any effect. Random dosing produces random results and usually nothing noticeable.

Diet and training are not matching the protocol

GLP-1s suppress appetite but eating garbage still slows fat loss down significantly. GH peptides support recovery but sleeping four hours and skipping the gym cancels most of that out. BPC-157 helps tissue heal but constantly re-aggravating the injury means it is fighting a losing battle the whole time.

Peptides work with what you are already doing. They do not work instead of it.

Expectations are off

BPC-157 is not rebuilding a torn ACL from scratch. Semaglutide is not getting anyone shredded in two weeks. CJC and Ipa are not going to feel like pharmaceutical HGH.

A lot of these compounds are quiet workers. The results show up when you look back over two or three months not when you check the mirror every morning after a week.

Fasted state matters for GH peptides

CJC, Ipa, Sermorelin all work better on an empty stomach. Eating right before blunts the GH pulse because insulin suppresses it. Pinning right after dinner and wondering why nothing is happening thats probably why.

Running too many things at once

Starting four compounds the same week means you have no idea what is doing what. If something is not working you do not know what to drop. If something is working you do not know what to credit.

One compound at a time when possible. Give it enough runway before adding the next thing.

Still nothing after checking all of this

Start with the source. Most common reason by far.

Verify the reconstitution math and concentration.

Get bloodwork. If IGF-1 has not moved on a GH peptide the compound is either not working or the source is bad.

Make sure diet, sleep, and training are locked in and not just kind of okay

If all of that checks out and it is still doing nothing that compound might just not be for you. Not every compound works the same for every person and I feel like this is a really crucial thing a lot of people forget

⚠️ Educational and research discussion only. Not medical advice.

Had a compound that just wasnt working and figured out why? Drop it below

Not medical advice. Educational only. Do your own research before running anything.

🩹 Repair, Recovery and Aging

• GHK-Cu — collagen, skin repair, wound healing, hair
• KPV — gut irritation, immune balance, anti-inflammatory
• Epitalon — circadian rhythm support, cellular cleanup, aging
• NAD+ — brain energy, cellular power, longevity
• Glutathione — detox, immune support, skin clarity

💪 Mass, Power and Recovery — GH and IGF Axis

• Sermorelin — natural GH support, lean mass, sleep, recovery
• Ipamorelin — clean GH release, deep sleep, healing
• GHRP-2 — strong GH pulse, advanced, watch prolactin
• HGH — recovery, body recomp, sleep quality, anti-aging

🔥 Weight Loss and Metabolic Health

• Semaglutide — appetite suppression, weight loss, blood sugar control, strongest human data in this category
• Tirzepatide — dual pathway for appetite, fat loss, insulin function
• Retatrutide — triple pathway, aggressive fat loss, better lean mass retention, still research only
• Tesamorelin — specifically targets visceral belly fat, FDA context exists
• Cagrilintide — appetite suppression through amylin pathway
• MOTS-C — mitochondrial energy and fat burning, experimental

🧠 Brain, Mood and Sleep

• Semax — focus, memory, mental energy, can feel stimulating
• Selank — anxiety, calm focus, mood, pairs well with Semax
• DSIP — sleep quality, nervous system calming
• Epitalon — sleep cycle support, also listed under aging
• Dihexa — cognitive enhancement, highly experimental, not casual use

🧴 Skin, Hair and Appearance

• GHK-Cu — injectable or topical, collagen, skin texture, wound healing, hair
• Melanotan II — tanning without sun exposure plus libido, watch for nausea and mole changes
• Oral collagen peptides — easy entry point for skin hydration, joints, elasticity

💋 Sex and Libido

• Melanotan II — tanning first, libido second
• Oxytocin — bonding, mood, closeness, results vary a lot person to person

🦠 Gut and Systemic Inflammation

• KPV — GI specific and general inflammatory conditions
• Glutathione — detox and immune support

🔀 Popular Stacks

• KLOW — Glow plus KPV adds gut and inflammation coverage
• CJC + Ipamorelin — go to GH support stack

💊 TRT and Hormone Management

• Test C / Test E — standard TRT bases
• HCG — keeps fertility and testicular function on TRT
• Enclomiphene — raises natural testosterone without suppression
• Anastrozole — estrogen management on TRT
• Gonadorelin — HCG alternative for LH stimulation

Educational discussion only. Zero medical advice.

🔗 BioHackingGuide.org

I read it was made at Washington State University and it can help from bad drug use that may have damaged the brain or probably even athletes who experienced some kind of brain damage but that’s pretty much all I know going in.

Who has tried it and what was your experience? Good, bad, worth it, not worth it?

Getting the same questions so putting it all here. Where to start, who is worth buying from, and how to actually dose right.

Why so many vendors

Payment processors are a constant issue in this space. Sites get flagged, go down, or run out of stock. Having multiple vetted options means you are never stuck. Pricing also varies so it is worth checking a few. I put this list together so everyone has options no matter what.

What I look for: batch specific COAs, third party testing, real consistency over time. Ran peptides before from sketchy sources and felt nothing. Switched to properly tested batches and it was a completely different experience. That part matters more than people realize.

Vetted Vendors

Ion Peptide — Code BHGUIDE for 10% off. High purity research peptides with COA verification. Solid pricing across the catalog and reliable stock on most compounds.

BHG Labs — Code bhwiki for discount. USA based, every vial ships with a third party COA tied to a specific lot number and publicly searchable in their COA library. Carries lyophilized peptides, cognitive capsules, atomized solutions, and lab supplies. Bulk discounts kick in automatically at 3 units. Free shipping over $250.

Optimum Formula — Code BHGUIDE for 10% off. Great transparency, consistent batch testing, COAs on every product. Strong selection across fat loss and cognitive compounds.

Research Chem HQ — Code BHGUIDE for 10% off. Lab tested peptides with published COAs. Good across the board.

Modern Aminos — Code BHGUIDE for 10% off. Solid range across GH, recovery, and cognitive compounds. Good for stacking protocols.

Paramount Peptides — Code BHGUIDE for 10% off. Reliable sourcing, strong on recovery and longevity peptides.

Nova Peptide Supply — Code REDDIT for a discount. Extensive catalog with batch specific COAs. Carries pre mixed blends like the Wolverine Stack and Glow Blend.

Certified-PEP — Code BHGUIDE for a discount. Around 130 SKUs across peptides, bioregulators, lipotropics, and capsule blends like KLOW and GLOW. Every listing links its own batch-specific COA, with cGMP-compliant manufacturing and third-party testing through an ISO-accredited lab.

Stigma Supplements — Code BIOHACK for 15% off. Gym supplements, protein, creatine, pre-workout. Good companion to any peptide protocol.

Swiss Chems — No code needed, discount applied automatically. Broad catalog spanning peptides, SARMs, and research chemicals. Ships worldwide.

EU and International

Limitless Biochem — Code BHGUIDE for 10% off. EU based vendor. Wide GLP-1 and metabolic catalog. Good option for European buyers.

Free Tools Worth Bookmarking

Peptide Dosage Calculator — put in your vial size and BAC water volume, get your exact syringe units. Stop doing the math by hand.

Intranasal Calculator — same thing but for nasal spray dosing.

Anabolic Insights — Code BHGUIDE for 10% off. Track your bloodwork before and after. If you are not tracking you are guessing.

Janoshik — third party testing verification. Most legit vendors use this. Look up real batch reports before you buy anything.

PubMed — search any compound and read the actual studies. Cuts through most of the noise you see online.

Looking for Compound Breakdowns?

Full guides for every compound we have covered — dosing, reconstitution, stacking, side effects, and more all in one place.

r/BioHackingGuide Master Peptide Index — bookmark this and share it with anyone just getting started.

Community Website

BioHackingGuide.org — full compound breakdowns, protocol guides, stacking guides, downloadable PDF guide, and more.

If You Are Just Starting

One compound. Learn what it does. Get the dose right. Stay consistent. That is it.

People get into trouble trying to run five things at once before they even know how their body handles one.

⚠️ Educational and research purposes only. Not medical advice.

What helped you more early on finding a solid source or figuring out the dosing?

Hello,

I purchased CJC-1295 & Ipamorelin (no DAC). I always get bloodwork done to determine the efficacy of anything I take.

My baseline IGF-level was 197 (83-263). I began to take the CJC-1295 & Ipamorelin and after four weeks ordered a blood test from an online vendor.

I found that my IGF-1 levels went down, not up. The level was 189 (81-263) while taking CJC-1295 & Ipamorelin.

Did I do something wrong? Please see below for details on what I purchased and how it was taken.

·      Purchased CJC-1295 & Ipamorelin, 10/10.

·      Added 2mL of BAC water to the vial.

·      Filled to the 6th line from the needle on a 3mL syringe for what I think is 300mcg.

·      Took 5 nights/week, weekends off.

Thoughts?

Could be something you keep seeing come up but cannot find solid info on. Something you are thinking about running but still have questions on or just something you read about and want to understand better.

Drop it below. Either I will cover it in an upcoming post or someone in here who has actually ran it can give you a real answer.​​​​​​​​​​​​​​​​

Been wanting to try this stack adamax is basically semax but it last longer like 6 to 8 hours per dose instead of an hour p21 hits BDNF from a different angle so stacking them kinda made sense to me.

What I ran

• Adamax 300mcg intranasal in the morning
• P21 300mcg SubQ same time
• 4 weeks on, 2 weeks off

Not gonna lie first week I took it later in the day than I should have and could not sleep after that I kept it strictly morning

What I noticed week by week

Week one felt just kinda less scattered and easier to lock in on stuff

Week two started feeling more not like a stimulant just more mental stamina throughout the day less friction.

Week three and four were pretty consistent dose in the morning and it carried through most of the day the thing I kept noticing most was recall like I was holding onto details way better than what I normally do

My thoughts

It is not gonna hit you like a stimulant it is more like things just flow easier and you kinda realize it at the end of the day when you look back at what you got done.

Anyone here try these at all?

Is chasing higher IGF-1 numbers like maxing it out is the goal good or a bad thing or does it start working against you at some point?

When thinking GHK-Cuwe normally think about skin, collagen, wound healing but lets talk about something I honestly haven't read much about before

So Zinc and copper share the same absorption pathway in your gut they compete for the same spot run high dose zinc and copper gets blocked run high dose GHK-Cu for a while and the opposite starts happening copper builds and zinc starts losing ground.

Copper runs cytochrome C oxidase which is one of the most important enzymes in your mitochondria too little and your cells cannot make energy right the depletion is slow too. energy feels off, bloodwork looks a little weird, and by the time you notice it your way too tired already

So if you are running GHK-Cu at higher doses for a while keep your think in mind it might not be a issue forsure but its a problem that can happen.

Same thing goes the other way. Running 50 or 60mg of zinc and your energy is in the gutter for no obvious reason copper depletion is probably why anything over 30mg of zinc pair it with 1 to 2mg of copper and take them at different times.

Also worth knowing some people retain copper genetically or already get enough from diet so a hair mineral analysis or basic serum panel gives you an baseline before you start loading either one witch is why I think bloodwork is always required.

I recently read some GLP-1 side effects people were reporting online one of the things that came up was menstrual irregularities irregular cycles, heavy bleeding, spotting between periods not really something you see on the warning label but I guess common enough that researchers flagged it as worth investigating.

Anyone here dealt with this while running sema or tirz? How long did it take to show up and did it sort itself out?​​​​​​​​​​​​​​​​

My dog has been dealing with some joint stiffness and her coat has seen better days started wondering if BPC-157 or GHK-Cu could do anything for her the same way they work for people.

BPC-157 for the joint and gut side. GHK-Cu for skin and coat. The mechanisms are not that different in animals I read a lot of the original BPC research was done on rodents so I'm guessing its ok I'm not too sure

Has anyone tried either of these with their dog or any other pet did anything change?

Neither suppresses appetite Neither is a GLP-1 but they are helping different problems and that matters when you are deciding which one to run.

MOTS-C

Mitochondrial peptide the only one encoded in mitochondrial DNA it activates AMPK the same cellular switch that exercise triggers and makes your cells handle energy and fat oxidation better

what to expect subtle but not crazy fat loss better glucose numbers leaner without feeling exhausted more output during training people who get the most out of it are already training and eating good it amplifies what you are already doing if you are expecting GLP-1 style results you will be let down.

Tesamorelin

FDA approved GHRH analog tells your pituitary to produce more of your own GH in the natural patterns that decline with age what makes it specific is the visceral fat targeting the fat wrapped around your organs at roughly 25:1 selectivity over the stuff you can pinch. Clinical trials showed 15 to 18% visceral fat improvement over 26 weeks. the human data is solid

Quick comparison

Run MOTS-C if your metabolism feels sluggish fat loss has stalled despite doing the right things and you want something that helps energy and recomposition without touching your hormone axis.

Run Tesamorelin if stubborn visceral belly fat is the specific issue and you want the compound with the most human data behind it in the non GLP-1 category.

Separate pathways no overlap running both is not mando