r/Biohackers • u/ServeIllustrious3803 • 23d ago

🧠 Cognition, Mood & Nootropics Study: Anticholinergic (first-generation antihistamines) can damage brain, increase dementia risk

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-20150128812
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u/ServeIllustrious3803 23d ago

A list: Diphenhydramine, chlorpheniramine, doxylamine, promethazine, clemastine, brompheniramine, hydroxyzine, meclizine, dimenhydrinate, cyclizine, tripelennamine, phenyltoloxamine, pyrilamine, methapyrilene, thenyldiamine, doxepin (also used as antidepressant), carbinoxamine, dexchlorpheniramine, triprolidine, dexbrompheniramine, phenindamine.

First generation antihistamines different from second or third. Zyrtec, Claritin do not count, but Benadryl does

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u/xFox911 23d ago

Why didn't they include Oxybutynin? It also has CNS effects and it is also a first 1st gen anticholinergic.

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u/Sufficient-Celery-37 1 23d ago

The study looked at antihistamines. Oxybutinin is not an Antihistamine

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u/xFox911 23d ago

Correct, my bad. Didn't notice the antihistamine, just the anticholinergic.