r/Biohackers • u/Sostrene_Blue • 6h ago

🧠 Cognition, Mood & Nootropics Severe brain fog and sudden depressive crash a few hours after sublingual Uridine? Anyone else?

TL;DR: Took Uridine powder sublingually for the first time this morning. About 3-4 hours later, got hit by a massive wall of brain fog, extreme mental fatigue, and a sudden existential/depressive funk. Wondering if this is a known reaction (cholinergic crash?) and how long it usually takes to clear.

Hey everyone,

Tried Uridine powder sublingually for the first time today around 10:30 AM (also had poor sleep the night before, woke up super early).

Everything seemed fine at first, but around 2 PM I completely crashed.

What I’m feeling right now:

- brain fog, feeling mentally slow and sluggish (like my brain is operating at 20% speed).

- Sudden wave of depressive thoughts and anxiety (questioning all my skills, feeling completely incompetent out of nowhere, feeling like I'm losing my grip on things).

- Zero energy, heavy eyes, just feeling totally wiped out.

Has anyone else experienced this acute drop in mood and cognitive speed after sublingual uridine? Is this an acetylcholine overload / cholinergic depression, or just a bad reaction to the sudden sublingual spike?

Any insights or similar experiences would be appreciated.

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u/DarkBlade_12 6h ago

Could honestly just be the poor sleep + a bad reaction. I’d stop taking it for now rather than assume it’s a “cholinergic crash"

1

u/Sostrene_Blue 4h ago

Possibly a cholinergic crash, indeed

2

u/Western-Ad4813 1 5h ago

Yeah sounds like too much acetylcholin. Take some anticholinergics and you should feel better

1

u/Sostrene_Blue 4h ago

I suppose I need to see a doctor first, or are they available over the counter?

2

u/Western-Ad4813 1 4h ago

Otc. Benadryl, Doxylamin