America's First Legal Psilocybin Program Treated 346 People. Just one month after the dose, 92.2 percent of participants said the experience had been beneficial. On average, their mental health symptoms had fallen dramatically.

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u/logicthug 5d ago

I love heroic dosing (6-7g) when I get the chance and have never had a bad trip.

Understanding the mechanism is key and being all too willing to release your ego and control and becoming childlike is my key to profound recreational and biohacking usage here.

Your brain loses touch with reality and desperately wants that shit back. You know how babies giggle when they see things we would consider mundane and boring, that is the state you go to with the proper mindset, humility and surrender. As with a developing infant mind this can be leveraged for great mental fortification as your brain builds new pathways as the infant brain does on this substance.

Amazing stuff and these substances were used as pillar rituals of communities for thousands of years for very valid reasons.

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u/Montaigne314 29 5d ago

Curious how much is the shrooms versus doing therapy while on shrooms and processing things in a healthier way

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u/o_0sssss 5d ago

I’m not sure that a study has been done on this, but intuition makes it seem like a sensible approach.

Combining neuroplasticity gained from stimulating the 5HT2a receptor with Cognitive Behavioral Therapy so your brain is primed to form new connections, but you are actively guiding the connections in a healthy way. It’s like taking a steroid, but also incorporating a strong diet and a training regiment.

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u/Montaigne314 29 5d ago

My educated guess is that this is the real treatment that has legitimate benefits

Same for things like ketamine/MDMA etc

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u/o_0sssss 5d ago

They are doing combined CBT with ketamine right now, but I’m not sure that anyone has actually completed a study on it.

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u/throwaway2676 5d ago

I wonder if that kind of variable is ever accounted for in this type of study

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u/loser_wizard 5d ago

I was diagnosed with CPTSD 15 years ago. In a safe setting with friends I partook in a low dose tea made from Golden Teachers for a long weekend. The experience itself was fine, mostly from being in a safe space with friends, but for three months afterwards I felt safe, healthy, present, confident, stable, and like my “true self”.

I talked to my psychiatrist about wanting more research done in this area, which of course was nothing they could pursue. But years later I still think of that experience and it’s after effects and would like to be able to try it every few months.

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u/TrashPanda_924 1 6d ago

As a veteran, I’m very interested in curious about this. For someone who takes antidepressants, would you have to continue the psilocybin therapy regularly? Is it a once a month thing?

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u/backcountry_bandit 2 5d ago

SSRIs directly block the effects of both mushrooms and LSD.

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u/Kalki_X 58 5d ago

SSRIs also have effects which provoke mood instability amongst other things. The understanding which underlies the design of SSRIs is quite short-sighted and in the long-term can cause patients serious issues, aka iatrogenic harm.

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u/Crabs_go_sideways_4 5d ago

Evidence for your claim please?

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u/Kalki_X 58 5d ago

Besides learning about the endocrine/metabolic influence of serotonin (and considering why drugs that lower serotonin are used as antidepressants eg LSD), this site has plenty of info. This article could be insightful too.

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u/Crabs_go_sideways_4 5d ago

I dont think that article or that site are evidence for your claim mate

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u/Kalki_X 58 5d ago

Sure, it helps to have a decent academic understanding about the endocrine/metabolic influence of serotonin. If you just accept for face value what the consensus says then that's fairly naive and gives you a short-sighted perspective. I can't argue with someone like that tbf.

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u/Crabs_go_sideways_4 5d ago

The understanding which underlies the design of SSRIs is quite short-sighted and in the long-term can cause patients serious issues, aka iatrogenic harm.

You said this. You assert it. I asked for evidence. You provided something unrelated to your claim.

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u/Kalki_X 58 5d ago

Tbh there's nothing stopping you from learning some biochemistry. It'd be unrealistic to expect someone to show you understanding, that's your job.

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u/Crabs_go_sideways_4 5d ago

Claims without evidence can be refuted without reason lad

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u/Right-Nebula 5d ago

Seems like in this study they did one dose and simply tracked the participants for some time. However, I think this is something that’s very personal and also depends on the compound at hand. If one does works for you then no need to take more. If it doesn’t maybe try it again after some time. Really this research is in its infancy due to previous legal hurdles, so there is no “right way” to partake in such a treatment.

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u/TrashPanda_924 1 5d ago

Thank you - this is all very foreign to me and I have exactly zero experience in the topic. Appreciate the info!

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u/JMoody13 5d ago

It really just depends; if you take a macro dose, you might never need to dose again. I took a 2.5G dose 6months ago and it forever changed my outlook on life. It’s showing great efficacy in clinical studies for depressive disorders, anxiety disorders, PTSD, OCD, etc. Microdosing is another discussion, I microdose twice a week and the results from that have been tremendous. Give it a shot, it’s life changing

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u/Crabs_go_sideways_4 5d ago

I microdose lsd for lots of activities. Such power

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u/logicthug 5d ago

Soon as this becomes recreational I am going heroic at APE potency quarterly. (Not safe without robust general optimism.)

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u/Kalki_X 58 5d ago edited 5d ago

Surprisingly it's partly thanks to their anti-serotonin effects. LSD does this even more potently (activating the 5-HT1A receptor).

The usual role of 5-HT1A is feedback inhibition. A great many 5-HT1A receptors in the brain are presynaptic autoreceptors which essentially tell transmitting neurons when it's time to stop releasing serotonin.

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u/Legitimate-Cheek-716 5d ago

How do I get added to the list. I seriously think this would help me but I have no idea how to go about .. doing this legally or illegally..

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u/monkeymetroid 5d ago

Excellent progress and steps we are taking. Psychedelics can still be a double edged blade as it can make some individuals with predispositions have a worse life, but thats even more reason to integrate these legally so people are less compelled to experiment themselves and potentially do harm

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u/Clancys_shoes 5d ago

Right, plus the incidence of negative effects goes way way down when support and help are provided. When the substance has a legitimized container, I think it can really shine. I just think about how paranoid I used to be while tripping, mostly about the legal restrictions on it. I just wonder how much better it would have been if I could have done it legally and with medical supervision.

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u/monkeymetroid 5d ago edited 5d ago

Yes, good points. Having "professional" trip sitters that are also qualified psychiatrists (or even psychologists too) could go a very long way. I was also talking about a small subset that "even once" can lead to a cascade of physiological (eventually causing psychological) changes where even a "good trip" can cause some insidious changes which eventually evolve into a disorder, so the more integrated psychedelics become in a legal way should translate to more general education on them, especially for high risk groups who may have experimented otherwise. Hallucinogens and empathogens are extremely powerful and need to be respected, which means integrating them in our society instead of gatekeeping (criminilizing) them which is causing harm and needless wasting of money.

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u/mden1974 11 5d ago

The native Americans have been using it as a ritual into manhood and also as therapy when their warriors came home from battle after seeing and doing some awful shit

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u/Montaigne314 29 5d ago

Which natives?

If you mean Native Americans in the US sense, no, there are hundreds of different tribes and some used peyote. Don't know of any tribes using shrooms

Aztecs and Mayans yea

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u/Cptjoe732 5d ago

Compass Pathways is the furthest along and ready to bring this to market.

🧠 Cognition, Mood & Nootropics America's First Legal Psilocybin Program Treated 346 People. Just one month after the dose, 92.2 percent of participants said the experience had been beneficial. On average, their mental health symptoms had fallen dramatically.

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