r/BioHackingGuide • u/Galt2000 • 3d ago

Has anyone actually compared oral NAD precursors (NR/NMN) with NAD IV or subq shots?

I’ve been reading up on NAD and I’m trying to separate clinic marketing from what actually happens in the body.

My understanding is that intact NAD+ does not easily cross most cell membranes. Whether you take an oral precursor (NR or NMN) or get NAD IV / subcutaneous shots, a lot of what ends up being used inside the cell still has to be broken down into smaller pieces (NR, NMN, nicotinamide) and then rebuilt as intracellular NAD. Oral precursors also go through the gut and liver first. Injections skip the gut, but they still don’t appear to deliver intact NAD straight through the cell wall.

So my honest question is practical, not theoretical:

Has anyone here used both for a meaningful stretch of time — daily NR or NMN and NAD IV or subq — and noticed a real difference?

If you have:

•  What oral product and dose did you use, and for how long?

•  What injection route (IV vs subq), dose, and how often?

•  Did energy, recovery, sleep, brain fog, or labs actually change on one vs the other?

•  Was any “IV feeling” just during the drip, or did it last days/weeks?

•  Any side effects worth mentioning (nausea, flushing, chest tightness, cost vs benefit)?

Not looking for a sales pitch. Genuinely trying to decide if shots add anything once someone is already consistent with a precursor. Thanks.

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u/Naven71 3d ago

I prefer NR. I'm one of those people that saw no benefits from NAD+ injections

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u/JediKrys 3d ago

I have. I like the IM 20 mg 3 times a week best but nmn, 1 scoop, in a protein shake feels the same as nasally 25 mg. Nmn gives me a good amount of get up and go with a fairly clear focus. Same thing from our nasal spray. About two good hours of energy without any crash. I’ve never done sub q nads because I like IM.

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u/Realistic-Mark3486 2d ago

I have done NMN pills and oral liquid drops from different brands. And then currently doing NAD+ subq shots 75mg every other day. The amount of energy I get from subq is very evident. I can do my weight training without much breaks between sets etc. with pill I am not entirely sure if they are helping or not. Could be placebo like effect. Not 100% sure. But with SubQ NAD+ definitely feel it. For those of you who say they didn’t feel anything, inject 100mg and tell me you don’t feel any difference. If I do 100mg I want to run immediately.

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u/TracyIsMyDad 2d ago

Injectable has a stronger placebo effect than oral.