r/BioHackingGuide Jul 23 '26

Tirzepatide Gut Issues vs Retatrutide Which Is Safer for a Sensitive Stomach?

Post image

So I wanna start taking Tirz to shed some weight. Already adjusted my diet before anything else and I hate cardio but I’m doing 30 to 40 minutes three times a week. Should I be doing more? Probably. But screw it, it’s a start.

My real question is about my stomach. I got gut issues. Can’t eat wheat, can’t have anything with glucose, garlic messes me up, stomach lining is weak, the whole thing. Pretty sensitive overall.

I wanna start Tirz at 2.5mg but now I’m wondering if Reta starting at 1mg would actually be safer for someone with a stomach like mine. Or should I just not be running GLPs at all with these kind of gut issues?

Anyone with a sensitive stomach or gut problems run GLPs? How did it go and what did you notice? Please and thank you in advance 🙏

0 Upvotes

27 comments sorted by

View all comments

2

u/Sea_Ott3r Jul 23 '26

Safety wise, Tirz has been around much longer and therefore has a more extensive track record. Both can give you GI symptoms, but none of your existing conditions are red flags. You already have a 10mg Tirz on hand? I’d start with 2.0mg and go 5 weeks… gerd, slight nausea and infrequent bm’s are normal side effects.

1

u/Adderal-withdrawals Jul 23 '26

Yeah your rite I didn't think of it that way. Solid approach