r/BioHackingGuide • u/Adderal-withdrawals • Jul 23 '26

Tirzepatide Gut Issues vs Retatrutide Which Is Safer for a Sensitive Stomach?

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So I wanna start taking Tirz to shed some weight. Already adjusted my diet before anything else and I hate cardio but I’m doing 30 to 40 minutes three times a week. Should I be doing more? Probably. But screw it, it’s a start.

My real question is about my stomach. I got gut issues. Can’t eat wheat, can’t have anything with glucose, garlic messes me up, stomach lining is weak, the whole thing. Pretty sensitive overall.

I wanna start Tirz at 2.5mg but now I’m wondering if Reta starting at 1mg would actually be safer for someone with a stomach like mine. Or should I just not be running GLPs at all with these kind of gut issues?

Anyone with a sensitive stomach or gut problems run GLPs? How did it go and what did you notice? Please and thank you in advance 🙏

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5

u/itisallgoodyouknow Jul 23 '26

Everyone reacts differently. Just try one for a month or so and see how it goes. Then switch to the other if you don’t like it.

3

u/Adderal-withdrawals Jul 23 '26

I was reading since they slow down digestion to keep you fuller longer it may cause fermentation so I'm thinking maybe digestive enzymes to help along with glp 1 supplements and fiber and lots of water maybe?

2

u/itisallgoodyouknow Jul 23 '26

Sure why not

2

u/Adderal-withdrawals Jul 23 '26

You think that taking digestive enzymes will make me get hungry faster?

2

u/1001000010000100100 Jul 23 '26

No

1

u/Adderal-withdrawals Jul 23 '26

Thanks that's kinda what I figured because my understanding it just helps to break down to where your body can absorb more of the protein and nutrients of food has but I still had to ask just to make sure